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   Articles with "pkp1" as a keyword



Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.

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recommendations! Published in 2020 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2020.12.193

Abstract: Plakophilin 1 (PKP1), a member of the armadillo repeat family of proteins, is a scaffold component of desmosomes, which are key structural components for cell-cell adhesion. However, PKP1 can be also found in the nucleus… read more here.

Keywords: pkp1; plakophilin; armadillo repeat; disordered protein ... See more keywords

Multi-omics analysis unveils a four-gene prognostic signature in esophageal squamous carcinoma and the therapeutic potential of PKP1

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recommendations! Published in 2025 at "BMC Cancer"

DOI: 10.1186/s12885-025-14150-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies, characterized by high heterogeneity and poor outcomes. Effective classification for patient stratification and identifying reliable markers for prognosis prediction and treatment choice are… read more here.

Keywords: pkp1; analysis; signature; cell ... See more keywords

PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP

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recommendations! Published in 2025 at "Biomarker Research"

DOI: 10.1186/s40364-025-00815-w

Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes in… read more here.

Keywords: pkp1 promotes; pkp1; cancer; pfkp ... See more keywords

Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP

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recommendations! Published in 2024 at "Biomolecules"

DOI: 10.3390/biom14050561

Abstract: Plakophilin 1 (PKP1), a member of the p120ctn subfamily of the armadillo (ARM)-repeat-containing proteins, is an important structural component of cell–cell adhesion scaffolds although it can also be ubiquitously found in the cytoplasm and the… read more here.

Keywords: repeat; pkp1; intrinsically disordered; plakophilin ... See more keywords