PKP2 induced by YAP/TEAD4 promotes malignant progression of gastric cancer
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23751
Abstract: Gastric cancer (GC) exhibits significant heterogeneity and its prognosis remains dismal. Therefore, it is essential to investigate new approaches for diagnosing and treating GC. Desmosome proteins are crucial for the advancement and growth of cancer.… read more here.
Keywords: yap tead4; progression; gastric cancer; pkp2 ... See more keywords
Pathogenic variants in plakophilin-2 gene (PKP2) are associated with better survival in arrhythmogenic right ventricular cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied genetics"
DOI: 10.1007/s13353-021-00647-y
Abstract: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is mainly caused by mutations in genes encoding desmosomal proteins. Variants in plakophilin-2 gene (PKP2) are the most common cause of the disease, associated with conventional ARVC phenotype. The study… read more here.
Keywords: arvc; ventricular cardiomyopathy; right ventricular; pkp2 ... See more keywords
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01692-x
Abstract: Radiation resistance is a major cause of lung cancer treatment failure. Armadillo (ARM) superfamily proteins participate in various fundamental cellular processes; however, whether ARM proteins regulate radiation resistance is not fully understood. Here, we used… read more here.
Keywords: catenin; radioresistance; pkp2; lung cancer ... See more keywords
Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Tissue barriers"
DOI: 10.1080/21688370.2022.2138061
Abstract: Previous data provided evidence for a critical role of desmosomes to stabilize intestinal epithelial barrier (IEB) function. These studies suggest that desmosomes not only contribute to intercellular adhesion but also play a role as signaling… read more here.
Keywords: barrier function; intestinal barrier; barrier; loss ... See more keywords
CineECG analysis of body surface potential mapping performed in preclinical and clinical plakophilin-2-variant carriers
Sign Up to like & getrecommendations! Published in 2024 at "Europace"
DOI: 10.1093/europace/euae102.659
Abstract: Abstract Background/introduction Pathogenic variation of the plakophilin-2 (PKP2) gene is associated with arrhythmogenic cardiomyopathy (ACM). Disease manifestation in PKP2-pathogenic variant (PV) carriers differs greatly. Early detection of disease is crucial and could be of benefit… read more here.
Keywords: pkp2 carriers; lead; bspm; activation ... See more keywords
Progressive Reduction in Right Ventricular Contractile Function Attributable to Altered Actin Expression in an Aging Mouse Model of Arrhythmogenic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.120.049261
Abstract: Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited genetic disorder of desmosomal dysfunction, and PKP2 (plakophilin-2) has been reported to be the most common disease-causing gene when mutation-positive. In the early concealed phase, the ACM heart… read more here.
Keywords: pkp2 het; pkp2; actin expression; contraction ... See more keywords
Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.121.057757
Abstract: Background: Exercise training, and catecholaminergic stimulation, increase the incidence of arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy correlated with plakophilin-2 (PKP2) mutations. Separate data show that reduced abundance of PKP2 leads to… read more here.
Keywords: ryanodine receptor; pkp2; deficient hearts; exercise ... See more keywords
A novel PKP2 mutation and intrafamilial phenotypic variability in ARVC/D
Sign Up to like & getrecommendations! Published in 2018 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.14196/mjiri.32.5
Abstract: Background: Arrhythmogenic ventricular cardiomyopathy (AVC) is an inherited cardiac disorder affecting 1 in 1000 individuals worldwide. The mean diagnosed age of disease is 31 years. In this article, an Iranian family reported that they were… read more here.
Keywords: phenotypic variability; pkp2; pkp2 mutation; mutation ... See more keywords
Phenotypic Variability of a Pathogenic PKP2 Mutation in an Italian Family Affected by Arrhythmogenic Cardiomyopathy and Juvenile Sudden Death: Considerations From Molecular Autopsy to Sport Restriction
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.635141
Abstract: Background: Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder with an estimated prevalence between 1:2,000 and 1:5,000 and is characterized by the fibrofatty replacement of cardiomyocytes that predisposes to malignant arrhythmias, heart failure, and sudden cardiac… read more here.
Keywords: death; family; pkp2; molecular autopsy ... See more keywords
Structural characterization and anti-inflammatory activity of a novel polysaccharide PKP2-1 from Polygonatum kingianum
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1156798
Abstract: Introduction This study aimed to investigate the structure characterization and antiinflammatory activity of a novel polysaccharide, PKP2-1, from the rhizomes of Polygonatum kingianum Coll. and Hemsl. Methods We isolated a novel polysaccharide, PKP2-1, from the… read more here.
Keywords: polygonatum kingianum; novel polysaccharide; polysaccharide pkp2; anti inflammatory ... See more keywords