Evidence for dispensability of protein kinase R in host control of tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747180
Abstract: Genetic deficiency of protein kinase R (PKR) in mice was reported to enhance macrophage activation in vitro in response to interferon‐γ (IFNγ) and to reduce the burden of Mycobacterium tuberculosis (Mtb) in vivo (Wu et… read more here.
Keywords: pkr; macrophage activation; tuberculosis; protein kinase ... See more keywords
RNA recognition by PKR during DNA virus infection
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29424
Abstract: Protein kinase R (PKR) is a double‐stranded RNA (dsRNA) binding protein that plays a crucial role in innate immunity during viral infection and can restrict both DNA and RNA viruses. The potency of its antiviral… read more here.
Keywords: virus infection; pkr; rna; infection ... See more keywords
Double-stranded RNA-dependent kinase PKR activates NF-κB pathway in acute pancreatitis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.080
Abstract: The activation of transcription factor nuclear factor kappa B (NF-κB) occurs early in acute pancreatitis (AP) simultaneously with intracellular trypsinogen activation. Double-stranded RNA-dependent kinase (PKR) promotes the activation of NF-κB and the production of pro-inflammatory… read more here.
Keywords: acute pancreatitis; kinase; ar42j cells; double stranded ... See more keywords
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.08.011
Abstract: Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in… read more here.
Keywords: pkr; inflammation mmp; pkr activation;
Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.01.024
Abstract: Hepatitis C virus (HCV) was shown to activate protein kinase R (PKR), which inhibits expression of interferon (IFN) and IFN-stimulated genes by controlling the translation of newly transcribed mRNAs. However, it is unknown exactly how… read more here.
Keywords: rna polymerase; polymerase; expression; activation ... See more keywords
PKR induces the expression of NLRP3 by regulating the NF‐&kgr;B pathway in Porphyromonas gingivalis‐infected osteoblasts
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.03.028
Abstract: ABSTRACT The double‐stranded RNA‐dependent kinase (PKR), which is activated by double stranded RNA, induces inflammation by regulating NF‐&kgr;B signaling. The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome also modulates inflammation in response to infection. Porphyromonas… read more here.
Keywords: expression nlrp3; inflammation; gingivalis; expression ... See more keywords
Structural Basis of Protein Kinase R Autophosphorylation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00161
Abstract: The RNA-activated protein kinase, PKR, is a key mediator of the innate immunity response to viral infection. Viral double-stranded RNAs induce PKR dimerization and autophosphorylation. The PKR kinase domain forms a back-to-back dimer. However, intermolecular… read more here.
Keywords: structural basis; kinase; back back; protein kinase ... See more keywords
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58433-x
Abstract: The innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases. The dsRNA-binding protein PACT plays a critical yet controversial… read more here.
Keywords: pact prevents; pkr; aberrant activation; pact ... See more keywords
High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92345-2
Abstract: Metabolic disorders are becoming more common in young population due to increased consumption of carbohydrate rich diet, lack of physical activity and stress. Fructose is used as a sweetener in many carbonated beverages and is… read more here.
Keywords: induced diabetic; diabetic impairments; pathway; high fructose ... See more keywords
Activation of PKR by a short-hairpin RNA
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-74477-3
Abstract: Recognition of viral infection often relies on the detection of double-stranded RNA (dsRNA), a process that is conserved in many different organisms. In mammals, proteins such as MDA5, RIG-I, OAS, and PKR detect viral dsRNA,… read more here.
Keywords: pkr activation; activation pkr; pkr; activation ... See more keywords
Viral evasion of PKR restriction by reprogramming cellular stress granules
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201169119
Abstract: Significance Evolutionarily conserved protein kinase R (PKR) is a powerful mediator of antiviral responses. Enigmatically, PKR activity is disabled by porcine reproductive and respiratory syndrome virus (PRRSV) during infection, while the virus still allows the… read more here.
Keywords: stress granules; pkr; evasion pkr; pkr restriction ... See more keywords