Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1012987
Abstract: The endoribonuclease (EndoU) nsp15 of coronaviruses plays a crucial role in evading host innate immune responses by reducing the abundance of viral double-stranded RNA (dsRNA). However, our understanding of its interactions with host cellular targets… read more here.
Keywords: host protein; protein; protein synthesis; pkr eif2 ... See more keywords
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS
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DOI: 10.7554/elife.85902
Abstract: GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. However,… read more here.
Keywords: pkr eif2; repeat; repeat expanded; expanded rnas ... See more keywords