Articles with "pks" as a keyword



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Transcriptional heterologous expression of two type III PKS from the lichen Cladonia uncialis

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Published in 2019 at "Mycological Progress"

DOI: 10.1007/s11557-019-01539-6

Abstract: Type III polyketide synthases (PKS) are an under-explored group of enzymes that are responsible for producing a variety of bioactive molecules. In a previous study, we identified two type III PKS genes (t3pks1 and t3pks2)… read more here.

Keywords: heterologous expression; iii pks; type iii; pks ... See more keywords
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Optimization of combustion characteristics of palm kernel-based biofuel for grate furnace

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Published in 2018 at "International Journal of Energy and Environmental Engineering"

DOI: 10.1007/s40095-018-0277-5

Abstract: Grate firing is one of the main competing technologies in biomass combustion for steam and electricity generation. Ash generated in the furnace during combustion process would greatly reduce the boiler thermal performance and may lead… read more here.

Keywords: palm kernel; combustion; grate furnace; combustion characteristics ... See more keywords
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Polymicrogyria with calcification in Pallister-Killian syndrome detected by microarray analysis

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Published in 2021 at "Brain and Development"

DOI: 10.1016/j.braindev.2020.11.003

Abstract: BACKGROUND Pallister-Killian syndrome (PKS) is a rare disorder caused by the mosaic tetrasomy of chromosome 12p, and is characterized by facial dysmorphism, developmental delay, hypotonia and seizures. RESULTS We report a patient with PKS showing… read more here.

Keywords: analysis; calcification; pallister killian; killian syndrome ... See more keywords
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Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate.

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Published in 2019 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2019.04.017

Abstract: Phosphoketolases (PK) are TPP-dependent enzymes which play essential roles in carbohydrate metabolism of numerous bacteria. Depending on the substrate specificity PKs can be subdivided into xylulose 5-phosphate (X5P) specific PKs (XPKs) and PKs which accept… read more here.

Keywords: pks; x5p; xylulose phosphate; structure ... See more keywords
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Boosting polyketides production in cell factories

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Published in 2020 at "Synthetic and Systems Biotechnology"

DOI: 10.1016/j.synbio.2020.02.002

Abstract: Polyketides (PKSs) are secondary metabolites produced by microorganisms with important pharmaceutical applications [1]. However, the production yield of these bioactive metabolites is often low in native hosts, largely because their biosynthetic gene clusters (BGCs) are… read more here.

Keywords: production; coa; tag; acetyl coa ... See more keywords
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Development of a cyanobacterial heterologous polyketide production platform.

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Published in 2018 at "Metabolic engineering"

DOI: 10.1016/j.ymben.2018.07.013

Abstract: The development of new heterologous hosts for polyketides production represents an excellent opportunity to expand the genomic, physiological, and biochemical backgrounds that better fit the sustainable production of these valuable molecules. Cyanobacteria are particularly attractive… read more here.

Keywords: production; cyanobacterial heterologous; platform; pks ... See more keywords
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A Type I/Type III PKS Hybrid Generates Cinnamomycin A-D.

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Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c00293

Abstract: 3,5-Dihydroxybenzoic acid (3,5-DHBA), biosynthesized by type III PKS and tailoring enzymes, is an unconventional starter unit for bacterial type I PKS. Genome mining of 3,5-DHBA-specific biosynthetic gene clusters could lead to discovering new type I/type… read more here.

Keywords: type type; type iii; pks; iii pks ... See more keywords
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Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.

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Published in 2020 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.0c07050

Abstract: Combinatorial biosynthesis with fungal polyketide synthases (PKSs) promises to produce unprecedented bioactive "unnatural" natural products (uNPs) for drug discovery. Genome mining of the dothideomycete Rhytidhysteron rufulum uncovered a collaborating highly reducing PKS (hrPKS) - nonreducing… read more here.

Keywords: polyketide synthases; product; chain length; pks ... See more keywords
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Gut Symbionts Lactobacillus reuteri R2lc and 2010 Encode a Polyketide Synthase Cluster That Activates the Mammalian Aryl Hydrocarbon Receptor

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Published in 2018 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.01661-18

Abstract: Temporary changes in the composition of the microbiota, for example, by oral administration of probiotics, can modulate the host immune system. However, the underlying mechanisms by which probiotics interact with the host are often unknown.… read more here.

Keywords: reuteri; ahr; r2lc 2010; host ... See more keywords
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Evolutionary Dynamics Based on Comparative Genomics of Pathogenic Escherichia coli Lineages Harboring Polyketide Synthase (pks) Island

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Published in 2021 at "mBio"

DOI: 10.1128/mbio.03634-20

Abstract: Extraintestinal pathologies caused by highly virulent strains of E. coli amount to clinical implications with high morbidity and mortality rates. Pathogenic E. coli strains are evolving with the horizontal acquisition of mobile genetic elements, including… read more here.

Keywords: island; coli; pks positive; clinical implications ... See more keywords

The Role of Fecal Fusobacterium nucleatum and pks+ Escherichia coli as Early Diagnostic Markers of Colorectal Cancer

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Published in 2021 at "Disease Markers"

DOI: 10.1155/2021/1171239

Abstract: Background Accurate analysis of intestinal microbiota will facilitate establishment of an evaluating system for assessing colorectal cancer (CRC) risk and prognosis. This study evaluates the potential role of Fusobacterium nucleatum (F. nucleatum) and Escherichia coli… read more here.

Keywords: pks; nucleatum pks; fusobacterium nucleatum; pks coli ... See more keywords