Intratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer
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DOI: 10.1038/s41416-023-02554-x
Abstract: This study aimed to investigate clinicopathological and molecular tumour features associated with intratumoral pks+Escherichia coli (pks+E.coli+), pks+E.coli- (non-E.coli bacteria harbouring the pks island), Enterotoxigenic Bacteroides fragilis (ETBF) and Fusobacterium nucleatum (F. nucleatum). We screened 1697… read more here.
Keywords: pks coli; cancer; enterotoxigenic bacteroides; pks ... See more keywords
Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults
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DOI: 10.1038/s41598-020-72245-7
Abstract: The relative contribution of diet to colorectal cancer (CRC) incidence is higher than that for other cancers. Animal models have revealed that Escherichia coli containing polyketide synthase (pks+ E. coli) in the gut participates in… read more here.
Keywords: dietary intake; intake; intake prevalence; prevalence pks ... See more keywords
The Role of Fecal Fusobacterium nucleatum and pks+ Escherichia coli as Early Diagnostic Markers of Colorectal Cancer
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DOI: 10.1155/2021/1171239
Abstract: Background Accurate analysis of intestinal microbiota will facilitate establishment of an evaluating system for assessing colorectal cancer (CRC) risk and prognosis. This study evaluates the potential role of Fusobacterium nucleatum (F. nucleatum) and Escherichia coli… read more here.
Keywords: pks; nucleatum pks; fusobacterium nucleatum; pks coli ... See more keywords
Vat-Mediated Mucus Penetration Enables Genotoxic Activity of pks+ Escherichia coli
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DOI: 10.3390/ijms26115353
Abstract: Colibactin toxin-producing Escherichia coli (pks+ E. coli) strains are associated with the occurrence of colorectal cancer in humans. These strains induce DNA damage when in close contact with the cells of the intestinal epithelium. Therefore,… read more here.
Keywords: escherichia coli; vat; pks coli; coli pks ... See more keywords