Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors.
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DOI: 10.1021/acschembio.2c00830
Abstract: Proteasome inhibitors with γ-lactam structure, such as lactacystin and salinosporamide A, have been isolated from actinomycetes and have attracted attention as lead compounds for anticancer drugs. Previously, we identified a unique enzyme TAS1, which is… read more here.
Keywords: compounds taslactams; proteasome inhibitors; pks hybrid; fungal nrps ... See more keywords