A NEW APPROACH FOR TREATMENT OF ULCERATIVE COLITIS: A MELANOCORTIN RECEPTOR AGONIST PL8177
Sign Up to like & getrecommendations! Published in 2024 at "Inflammatory Bowel Diseases"
DOI: 10.1093/ibd/izae020.003
Abstract: The melanocortin system plays an important role in resolving inflammatory processes. The melanocortin 1 receptor (MC1R)–specific agonist PL8177 has demonstrated MC1R binding affinity and functional activity that mirrors that of α-melanocyte–stimulating hormone. The effect of… read more here.
Keywords: pl8177; treatment; vehicle; colon ... See more keywords
Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1078678
Abstract: Background Melanocortins are peptides endowed with anti-inflammatory and pro-resolving activities. Many of these effects are mediated by the Melanocortin receptor 1 (MC1) as reported in several experimental settings. As such, MC1 can be a viable… read more here.
Keywords: mc1; pl8177; agonist pl8177; pro resolving ... See more keywords
A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1083333
Abstract: Introduction PL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel,… read more here.
Keywords: pl8177; formulation; rats dogs; melanocortin receptor ... See more keywords