Crystal structure of phospholipase A2 in complex with 1‐naphthaleneacetic acid
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1924
Abstract: Phospholipase A2 (PLA2) is one of the rate limiting enzymes involved in the production of arachidonic acid, a potent inflammatory mediator. PLA2 is widely distributed all over the animal kingdom. It is also seen in… read more here.
Keywords: crystal structure; phospholipase complex; pla2; phospholipase ... See more keywords
Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0079-5
Abstract: Targeting drugs to the inflamed intestinal tissue(s) represents a major advancement in the treatment of inflammatory bowel disease (IBD). In this work we present a powerful in-silico modeling approach to guide the molecular design of… read more here.
Keywords: bowel disease; inflammatory bowel; silico; pla2 ... See more keywords
Ruthenium chloride inhibits the anticoagulant activity of the phospholipase A2-dependent neurotoxin of Mojave rattlesnake Type A venom
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02479-3
Abstract: A unique nexus exists between coagulation and neurotoxicity that permits the assessment of the activity of destructive presynaptic phospholipase A2 (PLA2) enzymatic activity. This connection is that these enzymes can catalyze critical plasma phospholipids required… read more here.
Keywords: ruthenium; mojave rattlesnake; venom; anticoagulant activity ... See more keywords
Detection of phospholipase A2 in serum based on LRET mechanism between upconversion nanoparticles and SYBR green I.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.11.025
Abstract: Phospholipase A2 (PLA2) may be a vital biomarker for the prediction and diagnosis of some diseases. Consequently, it is of great significance to quantitatively detect PLA2 in biologic samples. Herein, on the basis of the… read more here.
Keywords: upconversion nanoparticles; detection; pla2; phospholipase ... See more keywords
Lysophosphatidylcholine in phospholipase A2-modified LDL triggers secretion of angiopoietin 2.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.04.007
Abstract: BACKGROUND AND AIMS Secretory phospholipase A2 (PLA2) hydrolyzes LDL phospholipids generating modified LDL particles (PLA2-LDL) with increased atherogenic properties. Exocytosis of Weibel-Palade bodies (WPB) releases angiopoietin 2 (Ang2) and externalizes P-selectin, which both play important… read more here.
Keywords: pla2 ldl; modified ldl; pla2; wpb exocytosis ... See more keywords
Influence of phospholipasic inhibition on neuromuscular activity of Bothrops fonsecai snake venom
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DOI: 10.1016/j.toxicon.2017.02.027
Abstract: &NA; Bothrops fonsecai (B. fonsecai), a pitviper endemic to southeastern Brazil, has a venom mainly composed by snake venom phospholipases (PLA2) and metalloproteases, compounds that could interfere with neuromuscular junction in vitro. In this work,… read more here.
Keywords: tyrode solution; venom; blockade; pla2 ... See more keywords
Immunogenicity of phospholipase A2 toxins and their role in Streptococcus equi pathogenicity.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.04.002
Abstract: Streptococcus equi subsp. equi (S. equi) is the causative agent of strangles, one of the most frequently diagnosed infectious diseases of horses worldwide. Phospholipase A2 toxins (PLA2) cleave phospholipid molecules at position sn-2 contributing to… read more here.
Keywords: streptococcus equi; phospholipase toxins; pla2;
Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.3c00097
Abstract: Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and inactive, are a central component in envenoming. These are responsible for disrupting the cell membrane’s integrity, inducing a wide range of pharmacological effects, such as… read more here.
Keywords: pla2; catalytically active; reaction; water ... See more keywords
Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
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DOI: 10.1038/s41467-021-24447-4
Abstract: Acute pancreatitis is a disease associated with suffering and high lethality. Although the disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar cells is a known pathogenic trigger. Here, we show macrophage membrane-coated… read more here.
Keywords: acute pancreatitis; pancreatitis; pla2; macrophage ... See more keywords
Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2102953118
Abstract: Significance Lp-PLA2 is a physiologically important human enzyme and an inflammatory biomarker for assessing risk factors associated with cardiovascular diseases. It is associated with low- and high-density lipoproteins in human plasma and acts on the… read more here.
Keywords: pla2; allosteric regulation; enzyme; specificity ... See more keywords
PLA2 mediates the innate immune response in Asian corn borer, Ostrinia furnacalis.
Sign Up to like & getrecommendations! Published in 2021 at "Insect science"
DOI: 10.1111/1744-7917.12932
Abstract: The eicosanoid signaling pathway mediates insect immune reactions to a wide range of stimuli. This pathway begins with the biosynthesis of arachidonic acid (AA) from the hydrolysis of phospholipids catalyzed by phospholipase A2 (PLA2 ).… read more here.
Keywords: innate immune; pla2; immune response; ostrinia furnacalis ... See more keywords