Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan
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DOI: 10.1038/s41598-022-07037-2
Abstract: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. We previously reported that the prevalence of phospholipase A2 receptor (PLA2R)- and thrombospondin type 1 domain containing 7A (THSD7A)-associated MN patients in Japan… read more here.
Keywords: pla2r; epidermal growth; exostosin; neural epidermal ... See more keywords
Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202209119
Abstract: Significance • Phospholipase A2 receptor (PLA2R) is the major autoantigen responsible for causing the rare autoimmune kidney disease, membranous nephropathy (MN).• PLA2R autoantibodies primarily bind to a dominant epitope located within a 28-amino acid peptide… read more here.
Keywords: epitope; pla2r; pla2r reveals; structure pla2r ... See more keywords
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2039705
Abstract: Abstract Background The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The… read more here.
Keywords: pla2r antibodies; anti pla2r; damage; pla2r ... See more keywords
Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1987080
Abstract: BACKGROUND AND PURPOSE Primary membranous nephropathy, also known as idiopathic membranous nephropathy, is an autoimmune disease. As an autoimmune disease, genetic factors are essential in the pathogenesis of IMN. People pay more and more attention… read more here.
Keywords: rs2715928; group; disease; allele ... See more keywords
Comparison of 2 Anti-PLA2R Immunoassays for the Diagnosis of Primary Membranous Nephropathy
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DOI: 10.1093/labmed/lmy016
Abstract: Background Anti-phospholipase A2 receptor (anti-PLA2R) is a promising biomarker for diagnosis, activity evaluation, therapy monitoring, and prognostic estimation of primary membranous neuropathy (pMN). Difference in methodology may be one cause of the discrepancy in anti-PLA2R-positive… read more here.
Keywords: primary membranous; anti pla2r; pla2r; iif elisa ... See more keywords
P0402TACROLIMUS PLUS LOW DOSE PREDNISOLONE THERAPY IS MORE EFFECTIVE IN PLA2R -VE MEMBRANOUS NEPHROPATHY PATIENTS
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0402
Abstract: Idiopathic Membranous Nephropathy (IMN); an autoimmune concomitant nephrotic syndrome of the adult is mainly associated with PLA2R antibody expressed on podocytes. The lack of exact mechanisms involved in the pathogenesis of IMN is transmitted to… read more here.
Keywords: low dose; membranous nephropathy; prednisolone; nephropathy patients ... See more keywords
Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis
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DOI: 10.1177/0961203319828521
Abstract: Background Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was… read more here.
Keywords: antibodies type; lupus nephritis; phospholipase receptor; lupus ... See more keywords
Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Autoantibody: One-Year Experience in Quebec’s Reference Center
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DOI: 10.1177/20543581211052729
Abstract: Background: Quantification of the M-type phospholipase A2 receptor antibodies (anti-PLA2R) is now an essential tool for diagnosis and management of primary membranous nephropathy (MN). Since October 2018, Hôpital Maisonneuve-Rosemont (HMR) has been designated as Quebec’s… read more here.
Keywords: year; anti pla2r; quebec; test ... See more keywords
Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study
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DOI: 10.1186/s12882-017-0636-0
Abstract: BackgroundAccording to renal M type phospholipase A2 receptor (PLA2R) immunohistochemistry, idiopathic membranous nephropathy (IMN) could be categorized into PLA2R-associated and non-PLA2R-associated IMN. We conducted a retrospective, multicenter cohort study with 91 patients to compare the… read more here.
Keywords: non pla2r; pla2r associated; pla2r; associated imn ... See more keywords
Can use of the serum anti-PLA2R antibody negate the need for a renal biopsy in primary membranous nephropathy?
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DOI: 10.1371/journal.pone.0281726
Abstract: Background Since the emergence of the anti-PLA2R antibody (PLA2R-Ab) test, nephrology practice has not changed dramatically, with most nephrologists still relying on a kidney biopsy to diagnose membranous nephropathy. In this study, we examined the… read more here.
Keywords: anti pla2r; pla2r; pla2r antibody; test ... See more keywords
A Proposal for a Serology-Based Approach to Membranous Nephropathy.
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DOI: 10.1681/asn.2016070776
Abstract: Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by autoantibodies against the recently discovered podocyte antigens: the M-type phospholipase A2 receptor 1 (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A). Assays for quantitative… read more here.
Keywords: serology; anti pla2r; serology based; membranous nephropathy ... See more keywords