Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3719
Abstract: The unique morphology and gene expression of podocytes are critical for kidney function, and their abnormalities lead to nephropathies such as diabetic nephropathy and membranous nephropathy. Podocytes cultured in vitro are valuable tools to dissect… read more here.
Keywords: pla2r1; cell; thsd7a; podocyte injury ... See more keywords
Current insights into functions of phospholipase A2 receptor in normal and cancer cells: More questions than answers.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.11.002
Abstract: Lipid signaling network was proposed as a potential target for cancer prevention and treatment. Several recent studies revealed that phospholipid metabolising enzyme, phospholipase A2 (PLA2), is a critical regulator of cancer accelerating pathologies and apoptosis… read more here.
Keywords: current insights; insights functions; phospholipase receptor; cancer ... See more keywords
Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/1324804
Abstract: The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy (MN). However, the pathogenic role of anti-PLA2R1 autoantibodies is unclear. Our aim was to evaluate the in vitro cytotoxicity of anti-PLA2R1 antibodies… read more here.
Keywords: anti pla2r1; vitro cytotoxicity; cytotoxicity; pla2r1 ... See more keywords
Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease
Sign Up to like & getrecommendations! Published in 2021 at "European Respiratory Journal"
DOI: 10.1183/13993003.00752-2020
Abstract: Background Cell senescence is a key process in age-associated dysfunction and diseases, notably chronic obstructive pulmonary disease (COPD). We previously identified phospholipase A2 receptor 1 (PLA2R1) as a positive regulator of cell senescence acting via… read more here.
Keywords: cell senescence; senescence; lung cell; pla2r1 ... See more keywords
Diverse effects of phospholipase A2 receptor expression on LNCaP and PC-3 prostate cancer cell growth in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26316
Abstract: Physiological and pathophysiological functions of the phospholipase A2 receptor 1 (PLA2R1) are still not completely understood. To elucidate PLA2R1’s function in prostate carcinoma, the receptor was ectopically overexpressed in LNCaP with silenced PLA2R1, and diminished… read more here.
Keywords: prostate; lncap; expression; receptor ... See more keywords
Immunological Pathogenesis of Membranous Nephropathy: Focus on PLA2R1 and Its Role
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01809
Abstract: Membranous nephropathy (MN) is the major cause of nephrotic syndrome with special pathological features, caused by the formation of immune complexes in the space between podocytes and the glomerular basement membrane. In idiopathic membranous nephropathy… read more here.
Keywords: immunological pathogenesis; pathogenesis; membranous nephropathy; nephropathy focus ... See more keywords