Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22697
Abstract: Alzheimer's disease (AD) is an irreversible and highly progressive neurodegenerative disease. Clinically, patients with AD display impairments in episodic and spatial memory. However, the underlying neuronal dysfunctions that result in these impairments remain poorly understood.… read more here.
Keywords: place cells; disease; model; place ... See more keywords
Spatial memory: Place cell activity is causally related to behavior
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.01.098
Abstract: A recent study using new holographic optogenetic stimulation technology has provided direct evidence that hippocampal place cell activity is sufficient to drive memory and navigation-related behaviors. read more here.
Keywords: cell activity; memory; place cell;
Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18351-6
Abstract: Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy… read more here.
Keywords: dentate gyrus; via competitive; place; competitive learning ... See more keywords
Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0225100
Abstract: The medial entorhinal cortex and the hippocampus are brain regions specialized in spatial information processing. While an animal navigates around an environment, grid cells in the medial entorhinal cortex spike at multiple discrete locations, forming… read more here.
Keywords: grid cell; spike; grid; cell ... See more keywords