Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22697
Abstract: Alzheimer's disease (AD) is an irreversible and highly progressive neurodegenerative disease. Clinically, patients with AD display impairments in episodic and spatial memory. However, the underlying neuronal dysfunctions that result in these impairments remain poorly understood.… read more here.
Keywords: place cells; disease; model; place ... See more keywords
Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4486
Abstract: Place cells in the CA1 region of the hippocampus express location-specific firing despite receiving a steady barrage of heterogeneously tuned excitatory inputs that should compromise output dynamic range and timing. We examined the role of… read more here.
Keywords: excitation enhances; place cells; heterogeneously tuned; excitation ... See more keywords
Making the case for place cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-020-00414-8
Abstract: Optogenetic stimulation of place cells alters memory-guided spatial navigation in mice, providing evidence for a causal role for these cells in spatial cognition. read more here.
Keywords: case place; making case; place; place cells ... See more keywords
Place cells may simply be memory cells: Memory compression leads to spatial tuning and history dependence.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2018422118
Abstract: The observation of place cells has suggested that the hippocampus plays a special role in encoding spatial information. However, place cell responses are modulated by several nonspatial variables and reported to be rather unstable. Here,… read more here.
Keywords: place cells; memory compression; may simply; cells may ... See more keywords
Spatial coding in the hippocampus and hyperpallium of flying owls.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212418120
Abstract: The elucidation of spatial coding in the hippocampus requires exploring diverse animal species. While robust place-cells are found in the mammalian hippocampus, much less is known about spatial coding in the hippocampus of birds. Here… read more here.
Keywords: spatial coding; place cells; coding hippocampus; flying owls ... See more keywords
Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1101/2022.06.13.495957
Abstract: A common way to study the functional importance of N-methyl-D-aspartate receptors (NMDARs) in hippocampal memory-encoding circuits is by administering NMDAR antagonists. We recently compared the effects of (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a competitive NMDAR antagonist, on… read more here.
Keywords: place cells; cells spatial; cpp; suppression ... See more keywords
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm1891
Abstract: Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires monitoring their subthreshold behavior. We probed the subthreshold dynamics using optogenetic depolarizing pulses in hippocampal neuronal assemblies in freely moving mice. Excitability… read more here.
Keywords: place cells; sharp wave; place fields; excitability ... See more keywords
Spatial memory deficits in Alzheimer’s disease and their connection to cognitive maps’ formation by place cells and grid cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.1082158
Abstract: Whenever we navigate through different contexts, we build a cognitive map: an internal representation of the territory. Spatial navigation is a complex skill that involves multiple types of information processing and integration. Place cells and… read more here.
Keywords: place cells; cells grid; alzheimer disease; grid cells ... See more keywords
A computational model of learning flexible navigation in a maze by layout-conforming replay of place cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2023.1053097
Abstract: Recent experimental observations have shown that the reactivation of hippocampal place cells (PC) during sleep or immobility depicts trajectories that can go around barriers and can flexibly adapt to a changing maze layout. Such layout-conforming… read more here.
Keywords: layout conforming; place cells; conforming replay; maze ... See more keywords
Scopolamine Impairs Spatial Information Recorded With “Miniscope” Calcium Imaging in Hippocampal Place Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.640350
Abstract: The hippocampus and associated cholinergic inputs have important roles in spatial memory in rodents. Muscarinic acetylcholine receptors (mAChRs) are involved in the communication of cholinergic signals and regulate spatial memory. They have been found to… read more here.
Keywords: calcium imaging; spatial information; memory; place cells ... See more keywords
Calcium Imaging Reveals Fast Tuning Dynamics of Hippocampal Place Cells and CA1 Population Activity during Free Exploration Task in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020638
Abstract: Hippocampal place cells are a well-known object in neuroscience, but their place field formation in the first moments of navigating in a novel environment remains an ill-defined process. To address these dynamics, we performed in… read more here.
Keywords: place cells; population activity; geometry; calcium ... See more keywords