Placebo Response to Oral Administration in Osteoarthritis Clinical Trials and Its Associated Factors
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.35060
Abstract: Key Points Question What are the oral placebo responses and associated factors of osteoarthritis in clinical trials? Findings In this model-based meta-analysis of 130 clinical trials with 12 673 participants, the placebo response on the Western… read more here.
Keywords: placebo response; clinical trials; osteoarthritis clinical; associated factors ... See more keywords
Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for Pain
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43848
Abstract: Key Points Question What is the size of the placebo response in cannabinoid trials for clinical pain, and is the magnitude of placebo response associated with media attention on the trials? Findings This meta-analysis of… read more here.
Keywords: clinical trials; placebo response; media attention; placebo ... See more keywords
Pediatric and Adult Placebo Response Rates in Placebo-Controlled Clinical Trials Submitted to the US FDA 2012-2020.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2035
Abstract: The use of placebo concurrent control (placebo-controlled) is the most rigorous method of evaluating the safety and efficacy of investigational treatments. However, the use of a placebo group in pediatric product development can be challenging… read more here.
Keywords: placebo response; response; placebo controlled; adult ... See more keywords
Assessing treatment benefit in the presence of placebo response using the sequential parallel comparison design.
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in medicine"
DOI: 10.1002/sim.9349
Abstract: In clinical trials, placebo response is considered a beneficial effect arising from multiple factors, including the patient's expectations for the treatment. Its presence makes the classical parallel study design suboptimal and can bias the inference.… read more here.
Keywords: design; placebo response; treatment; sequential parallel ... See more keywords
Does the increasing placebo response impact outcomes of adult and pediatric ADHD clinical trials? Data from the US Food and Drug Administration 2000-2009.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2017.07.018
Abstract: In a study of recent antidepressant clinical trial data, it was found placebo response had grown significantly over time and that contrary to expectations, trial outcome measures and success rate were not impacted. The aim… read more here.
Keywords: response; placebo response; drug; medication ... See more keywords
Placebo response mitigation with a participant-focused psychoeducational procedure: a randomized, single-blind, all placebo study in major depressive and psychotic disorders
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00911-5
Abstract: The remarkably high and growing placebo response rates in clinical trials for CNS indications, such as depression and schizophrenia, constitute a major challenge for the drug development enterprise. Despite extensive literature on participant expectancies and… read more here.
Keywords: participant focused; response; placebo response; major depressive ... See more keywords
Placebo Response as a Latent Characteristic: Application to Analysis of Sequential Parallel Comparison Design Studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Statistical Association"
DOI: 10.1080/01621459.2017.1375930
Abstract: ABSTRACT In clinical trials, placebo response can affect the inference about efficacy of the studied treatment. It is important to have a robust way to classify trial subjects with respect to their response to placebo.… read more here.
Keywords: response; latent characteristic; placebo response; response latent ... See more keywords
Placebo Response in Trials of Negative Symptoms in Schizophrenia: A Critical Reassessment of the Evidence
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbac061
Abstract: Abstract Background Summarizing evidence from clinical trials of patients with schizophrenia with predominant or prominent negative symptoms (NS), a prior meta-analysis reported a large placebo effect in negative symptoms (Cohen’s d = 2.909). Assuming that… read more here.
Keywords: negative symptoms; placebo response; effect; placebo ... See more keywords
Predictors of Placebo Response in Pharmacological Clinical Trials of Negative Symptoms in Schizophrenia: A Meta-regression Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbx192
Abstract: We conducted a meta-regression analysis of all double-blind, randomized, placebo-controlled clinical trials (DBRCTs) reporting effects of drug and placebo on negative symptoms in people with stable schizophrenia and predominant or prominent negative symptoms to assess… read more here.
Keywords: placebo response; meta regression; negative symptoms;
Factors with impact on magnitude of the placebo response in randomized, controlled, cross-over trials in peripheral neuropathic pain.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001964
Abstract: The presence and magnitude of placebo responses is important for the outcome in clinical trials of analgesics. This explorative study aimed at identifying patients and trial specific factors with impact on this response in randomized,… read more here.
Keywords: response; placebo response; specific factors; placebo ... See more keywords
Placebo response rate in patients with chronic constipation
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000019020
Abstract: Abstract Objective: The aim of this systematic review and meta-analysis is to calculate the pooled placebo response rate in patients with chronic constipation (CC) in randomized controlled trial (RCT) and its related factors. Method: This… read more here.
Keywords: patients chronic; response rate; rate patients; placebo response ... See more keywords