Placental barrier against COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.07.022
Abstract: Abstract Vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and possible induction of pregnancy complications, including miscarriage, fetal malformations, fetal growth restriction and/or stillbirth, are serious concerns for pregnant individuals with COVID-19. According… read more here.
Keywords: sars cov; barrier covid; placental barrier; vertical transmission ... See more keywords
Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.09.005
Abstract: The aims of this study are to quantify the protein levels of nucleoside transporters in placental microvillous membranes (MVMs) and to clarify the contributions of these transporters to ribavirin uptake at the placental barrier. Placental… read more here.
Keywords: ent2; ribavirin uptake; ent1 ent2; placental barrier ... See more keywords
Cysteamine and N-Acetyl-cysteine Alleviate Placental Oxidative Stress and Barrier Function Damage Induced by Deoxynivalenol.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00399
Abstract: Sows are highly sensitive to deoxynivalenol (DON) and susceptible to reproductive toxicity caused by oxidative stress, but the potential mechanisms and effective interventions remain unclear. Here, we investigated the role of two antioxidants (cysteamine and… read more here.
Keywords: function; placental oxidative; placental barrier; barrier ... See more keywords
Investigating the Use of Machine Learning Models to Understand the Drugs Permeability Across Placenta
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Access"
DOI: 10.1109/access.2023.3272987
Abstract: Owing to limited drug testing possibilities in pregnant population, the development of computational algorithms is crucial to predict the fate of drugs in the placental barrier; it could serve as an alternative to animal testing.… read more here.
Keywords: placental barrier; investigating use; machine learning; learning models ... See more keywords
Self‐assembled human placental model from trophoblast stem cells in a dynamic organ‐on‐a‐chip system
Sign Up to like & getrecommendations! Published in 2023 at "Cell Proliferation"
DOI: 10.1111/cpr.13469
Abstract: The placental barrier plays a key role in protecting the developing fetus from xenobiotics and exchanging substances between the fetus and mother. However, the trophoblast cell lines and animal models are often inadequate to recapitulate… read more here.
Keywords: placental barrier; trophoblast stem; human placental; model ... See more keywords
Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Women's Health"
DOI: 10.2147/ijwh.s393067
Abstract: Purpose As two of the most severe and common medical disorders during pregnancy, gestational diabetes mellitus (GDM) and hypertensive disorder complicating pregnancy (HDCP) cause adverse effects on placental barrier function and thus may lead to… read more here.
Keywords: placental barrier; pregnancy complications; group; mother fetus ... See more keywords
A Novel Multicellular Placental Barrier Model to Investigate the Effect of Maternal Aflatoxin B1 Exposure on Fetal-Side Neural Stem Cells
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15050312
Abstract: Ingestion of food toxins such as aflatoxin B1 (AFB1) during pregnancy may impair fetal neurodevelopment. However, animal model results may not be accurate due to the species’ differences, and testing on humans is ethically impermissible.… read more here.
Keywords: effect; neural stem; placental barrier; model ... See more keywords