Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.03.028
Abstract: Reduced placental blood flow results in placental ischemia, an initiating event in the pathophysiology of preeclampsia, a hypertensive pregnancy disorder. While studies show increased mortality risk from Alzheimer's disease, stroke, and cerebrovascular complications in women… read more here.
Keywords: placental ischemia; pregnancy; posterior cortical; cerebral edema ... See more keywords
Interactions between the complement and endothelin systems in normal pregnancy and following placental ischemia.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.06.015
Abstract: Preeclampsia is characterized by new onset hypertension and fetal growth restriction and is associated with aberrant activation of the innate immune complement system and stressed or ischemic placenta. Previous studies have suggested a role for… read more here.
Keywords: placental ischemia; pregnancy; complement; activation ... See more keywords
Abstract P208: Imaging The Longitudinal Reduction In Placental Ischemia In Response To Therapeutic Intervention For Preeclampsia
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.p208
Abstract: Preeclampsia is believed to be induced by abnormal vascular remodeling and the resulting placental ischemia during early development. Sildenafil, a phosphodiesterase-5 inhibitor, reduces the maternal symptoms of preeclampsia by promoting angiogenesis and enhancing NO-mediated vasodilation.… read more here.
Keywords: placental ischemia; response; rupp; preeclampsia ... See more keywords
Abstract 103: Il-33 Supplementation Improves Vascular Function And Maternal Hypertension In Response To Placental Ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hyp.79.suppl_1.103
Abstract: Preeclampsia (PE), a leading cause of maternal and fetal morbidity and mortality, is a hypertensive pregnancy disorder with end-organ damage that develops after 20 weeks of gestation. PE is characterized by chronic immune activation, endothelial… read more here.
Keywords: supplementation; hypertension; rupp; maternal hypertension ... See more keywords
In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.133172
Abstract: The impact of transient ischemic-hypoxemic insults on the developing fetal brain is poorly understood despite evidence suggesting an association with neurodevelopmental disorders such as schizophrenia and autism. To address this, we designed an aberrant uterine… read more here.
Keywords: placental ischemia; term; uterine hypercontractility; ischemia hypoxemia ... See more keywords
Perinatal Micro-Bleeds and Neuroinflammation in E19 Rat Fetuses Exposed to Utero-Placental Ischemia
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20164051
Abstract: Offspring of preeclampsia patients have an increased risk of developing neurological deficits and cognitive impairment. While low placental perfusion, common in preeclampsia and growth restriction, has been linked to neurological deficits, a causative link is… read more here.
Keywords: placental ischemia; micro bleeds; ischemia; exposed fetuses ... See more keywords