Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.01.016
Abstract: The malaria parasite Plasmodium falciparum presents antigens on the infected erythrocyte surface that bind human receptors expressed on the vascular endothelium. The VAR2CSA mediated binding to a distinct chondroitin sulphate A (CSA) is a crucial… read more here.
Keywords: var2csa; placental malaria; adenovirus encoded; encoded virus ... See more keywords
Increased Susceptibility to Plasmodium falciparum in Infants is associated with Low, not High, Placental Malaria Parasitemia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18574-6
Abstract: Risk of malaria in infants can be influenced by prenatal factors. In this study, the potential for placental parasitemia at delivery in predicting susceptibility of infants to Plasmodium falciparum (Pf) infections was evaluated. Seventy-two newborns… read more here.
Keywords: placental parasitemia; susceptibility; placental malaria; plasmodium falciparum ... See more keywords
Antibody mediated activation of natural killer cells in malaria exposed pregnant women
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83093-4
Abstract: Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated… read more here.
Keywords: placental malaria; antibody; pregnant women; mediated activation ... See more keywords
mSphere of Influence: Structural Insights into the Molecular Mechanism Underlying Placental Malaria
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00391-21
Abstract: Maria del Pilar Quintana works on immunology and pathogenesis of severe malaria. In this mSphere of Influence article, she reflects on how the papers “Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA” (R).… read more here.
Keywords: msphere influence; immunology; malaria; var2csa ... See more keywords
Age-modified factors associated with placental malaria in rural Burkina Faso
Sign Up to like & getrecommendations! Published in 2022 at "BMC Pregnancy and Childbirth"
DOI: 10.1186/s12884-022-04568-4
Abstract: Background Malaria in pregnancy can result in placental infection with fetal implications. This study aimed at assessing placental malaria (PM) prevalence and its associated factors in a cohort of pregnant women with peripheral malaria and… read more here.
Keywords: factors associated; age; aged years; placental malaria ... See more keywords
Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Malaria Journal"
DOI: 10.1186/s12936-017-2040-4
Abstract: AbstractBackgroundMalaria in pregnancy has been associated with maternal morbidity, placental malaria, and adverse birth outcomes. However, data are limited on the relationships between longitudinal measures of malaria during pregnancy, measures of placental malaria, and birth… read more here.
Keywords: placental malaria; adverse birth; pregnancy; birth outcomes ... See more keywords
Leptin, insulin like growth factor-I levels and histology-diagnosed placental malaria in an area characterized by unstable malaria transmission in central Sudan
Sign Up to like & getrecommendations! Published in 2017 at "F1000Research"
DOI: 10.12688/f1000research.10641.1
Abstract: Background: There are few published data on the association between leptin, insulin like growth factor-1 (IGF-1) and malaria during pregnancy. This study aimed to investigate maternal and umbilical cord leptin and IGF-1 levels and malaria during… read more here.
Keywords: placental malaria; insulin like; igf; like growth ... See more keywords
Pregnant women carrying female fetuses are at higher risk of placental malaria infection
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182394
Abstract: Background The pathophysiology of the placental malaria is not fully understood. If there is a fetal sex–specific susceptibility to malaria infection, this might add to the previous knowledge on the immunology, endocrinology and pathophysiology of… read more here.
Keywords: risk; malaria; placental malaria; malaria infections ... See more keywords
Impaired placental autophagy in placental malaria
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187291
Abstract: Background Placental malaria is a major cause of low birthweight, principally due to impaired fetal growth. Intervillositis, a local inflammatory response to placental malaria, is central to the pathogenesis of poor fetal growth as it… read more here.
Keywords: intervillositis; placental malaria; placental autophagy; fetal growth ... See more keywords
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011370
Abstract: VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous spaces of the placenta, leading to placental malaria (PM). Relatively high… read more here.
Keywords: epitope; conformational epitope; var2csa; placental malaria ... See more keywords
Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11050520
Abstract: The Plasmodium falciparum protein VAR2CSA allows infected erythrocytes to accumulate within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to placental malaria (PM) induce partial immunity against VAR2CSA, making it a promising vaccine… read more here.
Keywords: plasmodium falciparum; var2csa dbl3x; sequence; dbl3x domain ... See more keywords