Adenoviral mediated expression of anti-inflammatory progranulin by placental explants modulates endothelial cell activation by decrease of ICAM-1 expression.
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DOI: 10.1016/j.placenta.2019.12.018
Abstract: INTRODUCTION Functional disorders of the villous trophoblast may result in preeclampsia through the release of endothelial activating substances. Progranulin is an anti-inflammatory, pro-angiogenic cytokine with TNF-α antagonizing activity. The trophoblastic expression of progranulin is increased… read more here.
Keywords: anti inflammatory; endothelial cell; placental progranulin; progranulin ... See more keywords