Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.193
Abstract: Plakophilin 1 (PKP1), a member of the armadillo repeat family of proteins, is a scaffold component of desmosomes, which are key structural components for cell-cell adhesion. However, PKP1 can be also found in the nucleus… read more here.
Keywords: pkp1; plakophilin; armadillo repeat; disordered protein ... See more keywords
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.12.016
Abstract: Summary Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, thereby requiring a human model that recapitulates disease pathology and provides distinct readouts in… read more here.
Keywords: cell derived; derived cardiomyocytes; contractility; pathology ... See more keywords
Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms13876
Abstract: Cellular protein interaction networks are integral to host defence and immune signalling pathways, which are often hijacked by viruses via protein interactions. However, the comparative virus–host protein interaction networks and how these networks control host… read more here.
Keywords: protein; protein interactomes; viral infection; plakophilin ... See more keywords
Increased expression of plakophilin 3 is associated with poor prognosis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000014608
Abstract: Abstract Considering the essential role of plakophilin 3 (PKP3) in the maintenance cell-cell adhesion, dysregulation of PKP3 is involved in human diseases. This study aimed to explore the clinical significance of PKP3 in ovarian cancer.… read more here.
Keywords: expression; plakophilin; ovarian cancer; cancer ... See more keywords
“Orphan” Connexin43 in Plakophilin-2 Deficient Hearts Revealed by Volume Electron Microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.843687
Abstract: Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry of calcium into… read more here.
Keywords: electron microscopy; cx43; microscopy; plakophilin ... See more keywords
Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105529
Abstract: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore, we wanted… read more here.
Keywords: patients arvc; plakophilin; expression; right ventricular ... See more keywords