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   Articles with "planar cell" as a keyword



The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.07.087

Abstract: Proper cochlear hair cell array development and sensory apparatus positioning are achieved by planar cell polarity signaling. Effectors executing proper tissue development and maturation programs are largely unknown. We show that the actin nucleator Cobl… read more here.

Keywords: cell polarity; planar cell; polarity; cobl ... See more keywords

Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.

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recommendations! Published in 2017 at "Developmental biology"

DOI: 10.1016/j.ydbio.2017.06.003

Abstract: Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like… read more here.

Keywords: hair follicle; cell polarity; hair; follicle ... See more keywords

Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-024-55397-2

Abstract: Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior. Mutations… read more here.

Keywords: cell; cell polarity; planar cell; core protein ... See more keywords

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-62400-x

Abstract: FGF receptors play pivotal roles in morphogenetic processes, including vertebrate neurulation. Planar cell polarity signaling coordinates cell orientation in the tissue plane and is essential for neural tube closure. Here, we demonstrate abnormal planar polarity… read more here.

Keywords: phosphorylation; cell polarity; planar cell; polarity ... See more keywords
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Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-21718-x

Abstract: Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently… read more here.

Keywords: cell polarity; bone; bone mass; planar cell ... See more keywords

Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

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recommendations! Published in 2025 at "eLife"

DOI: 10.1101/2024.09.05.609312

Abstract: Body axis specification is a crucial event in animal embryogenesis and was an essential evolutionary innovation for founding the animal kingdom. It involves two distinct components that coordinate to establish the spatial organisation of the… read more here.

Keywords: body axis; planar cell; cell polarity; animal body ... See more keywords

ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2)/Planar Cell Polarity a New Pathway Controlling Endothelial Cell Polarity Under Flow Conditions.

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recommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"

DOI: 10.1161/atvbaha.123.319106

Abstract: BACKGROUND Endothelial cells (ECs) are sensitive to physical forces created by blood flow, especially to laminar shear stress. Among the cell responses to laminar flow, EC polarization against the flow direction emerges as a key… read more here.

Keywords: cell; ror2; cell polarity; planar cell ... See more keywords

Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate.

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recommendations! Published in 2021 at "Journal of cell science"

DOI: 10.1242/jcs.258864

Abstract: The orientation of epithelial cells in the plane of the tissue, known as planar cell polarity (PCP), is regulated by interactions of asymmetrically localized PCP protein complexes. In the Xenopus neural plate, Van Gogh-like2 (Vangl2)… read more here.

Keywords: cell polarity; neural plate; planar cell; cell ... See more keywords

Planar cell polarity protein-dependent basal cell height in the later stage embryonic mouse epidermis impacts on the shape of overlying suprabasal cells.

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recommendations! Published in 2022 at "Wellcome open research"

DOI: 10.12688/wellcomeopenres.17733.1

Abstract: Background: Complex organ formation requires the coordinated morphogenesis of adjacent tissue layers. Here, a role for the planar cell polarity (PCP) proteins Fz6 and Celsr1 in generating squamous basal cells in the later stage embryonic… read more here.

Keywords: cell; cell polarity; planar cell; basal ... See more keywords
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Planar cell polarity proteins determine basal cell height in the later stage embryonic mouse epidermis'

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recommendations! Published in 2023 at "Wellcome Open Research"

DOI: 10.12688/wellcomeopenres.17733.2

Abstract: Background: Complex organ formation requires the coordinated morphogenesis of adjacent tissue layers. Here, we report a role for the planar cell polarity (PCP) proteins Fz6 and Celsr1 in generating squamous basal cells in the later… read more here.

Keywords: cell; cell polarity; planar cell; basal ... See more keywords

Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment

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recommendations! Published in 2018 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1007391

Abstract: Planar cell polarity (PCP) instructs tissue patterning in a wide range of organisms from fruit flies to humans. PCP signaling coordinates cell behavior across tissues and is integrated by cells to couple cell fate identity… read more here.

Keywords: degradation; cell polarity; isoform; prickle ... See more keywords