The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.087
Abstract: Proper cochlear hair cell array development and sensory apparatus positioning are achieved by planar cell polarity signaling. Effectors executing proper tissue development and maturation programs are largely unknown. We show that the actin nucleator Cobl… read more here.
Keywords: cell polarity; planar cell; polarity; cobl ... See more keywords
Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.06.003
Abstract: Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like… read more here.
Keywords: hair follicle; cell polarity; hair; follicle ... See more keywords
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21718-x
Abstract: Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently… read more here.
Keywords: cell polarity; bone; bone mass; planar cell ... See more keywords
ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2)/Planar Cell Polarity a New Pathway Controlling Endothelial Cell Polarity Under Flow Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.123.319106
Abstract: BACKGROUND Endothelial cells (ECs) are sensitive to physical forces created by blood flow, especially to laminar shear stress. Among the cell responses to laminar flow, EC polarization against the flow direction emerges as a key… read more here.
Keywords: cell; ror2; cell polarity; planar cell ... See more keywords
Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.258864
Abstract: The orientation of epithelial cells in the plane of the tissue, known as planar cell polarity (PCP), is regulated by interactions of asymmetrically localized PCP protein complexes. In the Xenopus neural plate, Van Gogh-like2 (Vangl2)… read more here.
Keywords: cell polarity; neural plate; planar cell; cell ... See more keywords
Planar cell polarity protein-dependent basal cell height in the later stage embryonic mouse epidermis impacts on the shape of overlying suprabasal cells.
Sign Up to like & getrecommendations! Published in 2022 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.17733.1
Abstract: Background: Complex organ formation requires the coordinated morphogenesis of adjacent tissue layers. Here, a role for the planar cell polarity (PCP) proteins Fz6 and Celsr1 in generating squamous basal cells in the later stage embryonic… read more here.
Keywords: cell; cell polarity; planar cell; basal ... See more keywords
Planar cell polarity proteins determine basal cell height in the later stage embryonic mouse epidermis'
Sign Up to like & getrecommendations! Published in 2023 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.17733.2
Abstract: Background: Complex organ formation requires the coordinated morphogenesis of adjacent tissue layers. Here, we report a role for the planar cell polarity (PCP) proteins Fz6 and Celsr1 in generating squamous basal cells in the later… read more here.
Keywords: cell; cell polarity; planar cell; basal ... See more keywords
Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007391
Abstract: Planar cell polarity (PCP) instructs tissue patterning in a wide range of organisms from fruit flies to humans. PCP signaling coordinates cell behavior across tissues and is integrated by cells to couple cell fate identity… read more here.
Keywords: degradation; cell polarity; isoform; prickle ... See more keywords
Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201745409
Abstract: Planar cell polarity (PCP) describes a cell–cell communication process through which individual cells coordinate and align within the plane of a tissue. In this study, we show that overexpression of Fuz, a PCP gene, triggers… read more here.
Keywords: cell polarity; fuz; planar cell; gene ... See more keywords
Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1064907
Abstract: Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis. Like its Drosophila ortholog, Flamingo, mammalian… read more here.
Keywords: celsr1; planar cell; pcp; celsr1 celsr2 ... See more keywords
Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.976182
Abstract: Planar cell polarity (PCP) signaling polarizes cells within the plane of an epithelium. In the airways, planar cell polarity signaling orients the directional beating of motile cilia required for effective mucociliary clearance. The planar cell… read more here.
Keywords: cell; cell polarity; planar cell; airway epithelium ... See more keywords