Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.02.106
Abstract: Plant-made virus-like particle (VLP) vaccines that display wild-type influenza hemagglutinin (HA) are rapidly advancing through clinical trials. Produced by transient transfection of Nicotiana benthamiana, these novel vaccines are unusually immunogenic, eliciting both humoral and cellular… read more here.
Keywords: microscopy; virus like; electron microscopy; made virus ... See more keywords
The potential of plant-made vaccines to fight picornavirus
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2020.1791090
Abstract: ABSTRACT Introduction Several Picornaviruses are pathogens that generate serious problems for human and animal health worldwide. Vaccination is an attractive approach to fight against picornaviruses. In this regard, the development of low-cost vaccines is a… read more here.
Keywords: made vaccines; plant; vaccines fight; fight picornavirus ... See more keywords
The potency and synergy of plant‐made monoclonal antibodies against the BA.5 variant of SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13980
Abstract: Variable region sequences for light chain (LC) and heavy chain (HC) of cilgavimab and tixagevimab from literature (Dong et al., 2021) were synthesized by GENEWIZ and were genetically fused to a human kappa constant sequence… read more here.
Keywords: made monoclonal; plant made; potency synergy; plant ... See more keywords
Plant-Made Antibodies: Properties and Therapeutic Applications.
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DOI: 10.2174/0929867325666171212093257
Abstract: BACKGROUND A cost-effective plant platform for therapeutic monoclonal antibody production is both flexible and scalable. Plant cells have mechanisms for protein synthesis and posttranslational modification, including glycosylation, similar to those in animal cells. However, plants… read more here.
Keywords: antibodies properties; animal cells; plant; properties therapeutic ... See more keywords
A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant
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DOI: 10.3389/fimmu.2020.576012
Abstract: Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions. In this study, we systematically compared the… read more here.
Keywords: fusion; vaccine; plant made; igg fusions ... See more keywords
Plant-made poliovirus vaccines – Safe alternatives for global vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1046346
Abstract: Human polioviruses are highly infectious viruses that are spread mainly through the fecal-oral route. Infection of the central nervous system frequently results in irreversible paralysis, a disease called poliomyelitis. Children under five years are mainly… read more here.
Keywords: poliovirus; vaccination; poliovirus vaccines; plant made ... See more keywords
Recent Progress on Vaccines Produced in Transgenic Plants
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DOI: 10.3390/vaccines10111861
Abstract: The development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are… read more here.
Keywords: recent progress; progress vaccines; plant made; transgenic plants ... See more keywords