Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02287
Abstract: Dysregulation of cathepsin B, which involves the translocation of the enzyme from acidic pH lysosomes to the neutral pH cytosol, followed by the initiation of cell death and inflammation, occurs in numerous brain disorders. The… read more here.
Keywords: cathepsin; marine plant; acidic neutral; plant natural ... See more keywords
MULTI-SCULPT: Multiplex Integration via Selective, CRISPR-Mediated, Ultralong Pathway Transformation in Yeast for Plant Natural Product Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00135
Abstract: Yeast has been a versatile model host for complex and valuable natural product biosynthesis via the reconstruction of heterologous biosynthetic pathways. Recent advances in natural product pathway elucidation have uncovered many large and complicated plant… read more here.
Keywords: natural product; pathway; integration; plant natural ... See more keywords
Plant Natural Compounds in the Treatment of Adrenocortical Tumors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Endocrinology"
DOI: 10.1155/2021/5516285
Abstract: Plant natural products are a plethora of diverse and complex molecules produced by the plant secondary metabolism. Among these, many can reserve beneficial or curative properties when employed to treat human diseases. Even in cancer,… read more here.
Keywords: natural compounds; plant; plant natural; compounds treatment ... See more keywords
Microbial Cell Factory for Efficiently Synthesizing Plant Natural Products via Optimizing the Location and Adaptation of Pathway on Genome Scale
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00969
Abstract: Plant natural products (PNPs) possess important pharmacological activities and are widely used in cosmetics, health care products, and as food additives. Currently, most PNPs are mainly extracted from cultivated plants, and the yield is limited… read more here.
Keywords: location; natural products; plant natural; adaptation ... See more keywords
Oxidative Stress, Plant Natural Antioxidants, and Obesity
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DOI: 10.3390/ijms22041786
Abstract: Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of mitochondrial activity, modifying the concentration of inflammation mediators associated with a large number and size of adipocytes, promoting lipogenesis, stimulating differentiation of… read more here.
Keywords: plant natural; stress plant; stress; natural antioxidants ... See more keywords
Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis
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DOI: 10.3390/metabo10010037
Abstract: Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be… read more here.
Keywords: plant; natural products; analysis; plant natural ... See more keywords
Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases
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DOI: 10.3390/molecules28010043
Abstract: In plants, methylation is a common step in specialized metabolic pathways, leading to a vast diversity of natural products. The methylation of these small molecules is catalyzed by S-adenosyl-l-methionine (SAM)-dependent methyltransferases, which are categorized based… read more here.
Keywords: diversification; plant natural; plant; natural product ... See more keywords
Plant natural products for cognitive impairment: A review of the preclinical evidence
Sign Up to like & getrecommendations! Published in 2020 at "journal of applied pharmaceutical science"
DOI: 10.7324/japs.2021.110601
Abstract: Cognitive impairment (CI) is a highly complex central nervous system disorder commonly associated with aging. This condition is characterized by a progressive reduction of cognitive function. Modern synthetic drugs have been granted clinical approval for… read more here.
Keywords: review; medicinal plants; cognitive impairment; plant natural ... See more keywords