A Novel Plant-Produced Asialo-rhuEPO Protects Brain from Ischemic Damage Without Erythropoietic Action.
Sign Up to like & getrecommendations! Published in 2021 at "Translational stroke research"
DOI: 10.1007/s12975-021-00943-z
Abstract: Mammalian cell-produced recombinant human erythropoietin (rhuEPOM) has been shown to be a multimodal neuroprotectant targeting an array of key pathological mechanisms in experimental stroke models. However, the rhuEPOM clinical trials were terminated due to increased… read more here.
Keywords: plant; rhuepo; novel plant; plant produced ... See more keywords
Plant-produced recombinant Osteopontin-Fc fusion protein enhanced osteogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Reports"
DOI: 10.1016/j.btre.2019.e00312
Abstract: Highlights • Osteopontin (OPN) plays an important role in the bone regeneration process.• The plant-produced OPN-Fc increases the protein expression level and facilitates the purification of the recombinant protein.• The plant-produced OPN-Fc can stimulate the… read more here.
Keywords: protein; produced opn; plant; recombinant osteopontin ... See more keywords
Plant-produced bacteriocins inhibit plant pathogens and confer disease resistance in tomato.
Sign Up to like & getrecommendations! Published in 2021 at "New biotechnology"
DOI: 10.1016/j.nbt.2021.03.003
Abstract: Bacteriocins are a diverse group of bacterial antimicrobial peptides (AMPs) that represent potential replacements for current antibiotics due to their novel modes of action. At present, production costs are a key constraint to the use… read more here.
Keywords: production; plant; tomato; plant produced ... See more keywords
Exploring Site-Specific N-Glycosylation of HEK293 and Plant-Produced Human IgA Isotypes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.7b00121
Abstract: The full potential of recombinant Immunoglobulin A as therapeutic antibody is not fully explored, owing to the fact that structure–function relationships of these extensively glycosylated proteins are not well understood. Here monomeric IgA1, IgA2m(1), and… read more here.
Keywords: plant; site specific; hek293; plant produced ... See more keywords
Plant-Produced Chimeric VHH-sIgA Against Enterohemorrhagic E. coli Intimin Shows Cross-Serotype Inhibition of Bacterial Adhesion to Epithelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00270
Abstract: Enterohemorrhagic Escherichia coli (EHEC) has consistently been one of the foremost foodborne pathogen threats worldwide based on the past 30 years of surveillance. EHEC primarily colonizes the bovine gastrointestinal (GI) tract from which it can… read more here.
Keywords: epithelial cells; cross serotype; plant; produced chimeric ... See more keywords
Functional Characterization of Pembrolizumab Produced in Nicotiana benthamiana Using a Rapid Transient Expression System
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.736299
Abstract: The striking innovation and clinical success of immune checkpoint inhibitors (ICIs) have undoubtedly contributed to a breakthrough in cancer immunotherapy. Generally, ICIs produced in mammalian cells requires high investment, production costs, and involves time consuming… read more here.
Keywords: transient expression; production; plant; plant produced ... See more keywords
Resveratrol Oligomers, Plant-Produced Natural Products With Anti-virulence and Plant Immune-Priming Roles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.885625
Abstract: Antibiotic resistance has become increasingly prevalent in the environment. Many alternative strategies have been proposed for the treatment and prevention of diverse diseases in agriculture. Among them, the modulation of bacterial virulence to bypass antibiotic… read more here.
Keywords: plant immune; plant produced; immune priming; resveratrol oligomers ... See more keywords
A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1146234
Abstract: Molecular farming of vaccines has been heralded as a cheap, safe and scalable production platform. In reality, however, differences in the plant biosynthetic machinery, compared to mammalian cells, can complicate the production of viral glycoproteins.… read more here.
Keywords: plant produced; plant; mammalian cell; antigen ... See more keywords
Design of a Diagnostic Immunoassay for Aflatoxin M1 Based on a Plant-Produced Antibody
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14120851
Abstract: A new green competitive ELISA for aflatoxin M1 quantification in raw milk was developed. This diagnostic tool is based on an anti AFM1 mAb produced by plant molecular farming in alternative to classical systems. Our… read more here.
Keywords: design diagnostic; plant produced; based plant; plant ... See more keywords
Plant-Produced S1 Subunit Protein of SARS-CoV-2 Elicits Immunogenic Responses in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10111961
Abstract: SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic. The virus spreads rapidly with a high transmission rate among humans, and hence virus management has been challenging owing to finding specific therapies or vaccinations. Hence, an… read more here.
Keywords: produced subunit; subunit protein; sars cov; plant produced ... See more keywords
A Plant-Produced Recombinant Fusion Protein-Based Newcastle Disease Subunit Vaccine and Rapid Differential Diagnosis Platform
Sign Up to like & getrecommendations! Published in 2020 at "Vaccines"
DOI: 10.3390/vaccines8010122
Abstract: Newcastle disease (ND) is a highly contagious avian disease, causing considerable economic losses to the poultry industry. To obtain a safe, inexpensive, and effective ND vaccine to meet the international trade requirements of differentiating infected… read more here.
Keywords: protein; vaccine; plant produced; newcastle disease ... See more keywords