Oxidized lipids in atherosclerotic plaque instability
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.021
Abstract: A large body of evidence suggests a mechanistic link between oxidized lipids and atherosclerosis. Oxysterols and 4-hydroxynonenal (HNE), the major products deriving from LDL oxidation, are consistently present in inflamed and atherosclerotic arteries and they… read more here.
Keywords: oxidized lipids; plaque; oxysterols hne; plaque instability ... See more keywords
Up‐regulation of COX‐2 and mPGES‐1 by 27‐hydroxycholesterol and 4‐hydroxynonenal: A crucial role in atherosclerotic plaque instability
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.09.046
Abstract: &NA; Atherosclerosis is currently understood to be mainly the consequence of a complicated inflammatory process at the different stages of plaque development. Among the several inflammatory molecules involved, up‐regulation of the functional cyclooxygenase 2/membrane‐bound prostaglandin… read more here.
Keywords: cox mpges; plaque instability; regulation;
47 Novel inflammatory biomarkers of coronary plaque instability and rupture
Sign Up to like & getrecommendations! Published in 2017 at "Heart"
DOI: 10.1136/heartjnl-2017-ics17.47
Abstract: Background Plaque inflammation precipitates rupture the sequel of which is coronary thrombosis and myocardial cell death. A panel of inflammatory biomarkers to detect plaque instability may increase diagnostic accuracy in chest pain patients. Interleukin 15… read more here.
Keywords: rupture; chest pain; inflammatory biomarkers; plaque instability ... See more keywords
Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability: Implications for Healing.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.119.042192
Abstract: December 3, 2019 1857 Mark Brezinski, MD, PhD Frank Willard, PhD Maria Rupnick, MD, PhD I t is a widely believed paradigm that intimal angiogenesis in coronary atherosclerosis contributes to plaque instability through both hemorrhagic… read more here.
Keywords: intimal angiogenesis; plaque; plaque instability; angiogenesis ... See more keywords
Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitor Dapagliflozin Stabilizes Diabetes-Induced Atherosclerotic Plaque Instability.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.121.022761
Abstract: Background Diabetes is known to accelerate atherosclerosis and increase plaque instability. However, there has been a lack of suitable animal models to study the effect of diabetes on plaque instability. We hypothesized that the tandem… read more here.
Keywords: instability; glucose transporter; plaque instability; model ... See more keywords
CD4+/CD8+ ratio positively correlates with coronary plaque instability in unstable angina pectoris patients but fails to predict major adverse cardiovascular events
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/2040622320922020
Abstract: Background: The association between CD4+/CD8+ ratio and coronary plaque instability in patients with unstable angina pectoris (UAP) has not been investigated. We sought to elucidate the correlation between CD4+/CD8+ ratio and plaque instability in this… read more here.
Keywords: cd8 ratio; plaque instability; cd4 cd8;
Involvement of enhanced expression of classical complement C1q in atherosclerosis progression and plaque instability: C1q as an indicator of clinical outcome
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262413
Abstract: Activation of the classical complement pathway plays a major role in regulating atherosclerosis progression, and it is believed to have both proatherogenic and atheroprotective effects. This study focused on C1q, the first protein in the… read more here.
Keywords: atherosclerosis progression; plaque instability; progression; c1q ... See more keywords
Letter to the Editor. Carotid atherosclerotic plaque instability and cognition: collecting additional data.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurosurgery"
DOI: 10.3171/2018.5.jns181177
Abstract: TO THE EDITOR: We have read with great attention the article by Dempsey and colleagues3 (Dempsey RJ, Varghese T, Jackson DC, et al: Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in… read more here.
Keywords: instability; carotid atherosclerotic; plaque; plaque instability ... See more keywords
Immune Mechanisms of Plaque Instability
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.797046
Abstract: Inflammation crucially drives atherosclerosis from disease initiation to the emergence of clinical complications. Targeting pivotal inflammatory pathways without compromising the host defense could compliment therapy with lipid-lowering agents, anti-hypertensive treatment, and lifestyle interventions to address… read more here.
Keywords: role; immune mechanisms; plaque instability; risk ... See more keywords
The lymphocyte-to-monocyte ratio predicts intracranial atherosclerotic stenosis plaque instability
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.915126
Abstract: Background and purpose Gadolinium enhancement on high-resolution vessel wall imaging (HR-VWI) is an imaging marker of intracranial atherosclerotic stenosis (ICAS) plaque instability. This study aimed to evaluate the relationships between hematological inflammatory indicators and the… read more here.
Keywords: ratio; plaque instability; plaque; plaque enhancement ... See more keywords