Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis.
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DOI: 10.1016/j.vph.2018.12.004
Abstract: BACKGROUND AND AIMS Inhibition of the mechanistic target of rapamycin (mTOR) is a promising approach to halt atherogenesis in different animal models. This study evaluated whether the mTOR inhibitor everolimus can stabilize pre-existing plaques, prevent… read more here.
Keywords: advanced atherosclerosis; intraplaque neovascularization; everolimus; plaque macrophages ... See more keywords