Microfluidic enrichment of plasma cells improves treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12201
Abstract: Cytogenetic alterations form the basis for risk stratification for multiple myeloma (MM) and guide the selection of therapy; however, current pathology assays performed on bone marrow samples can produce false‐negatives due to the unpredictable distribution… read more here.
Keywords: cytogenetic alterations; multiple myeloma; plasma cells; cd45 ... See more keywords
Overexpression of the energy metabolism transcriptome within clonal plasma cells is associated with the pathogenesis and outcomes of patients with multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26577
Abstract: Altered energy metabolism and changes in glycolytic and oxidative phosphorylation pathways are hallmarks of all cancer cells. The expression of select genes associated with the production of various enzymes and proteins involved in glycolysis and… read more here.
Keywords: clonal plasma; plasma cells; energy metabolism; multiple myeloma ... See more keywords
Following nature's roadmap: folding factors from plasma cells led to improvements in antibody secretion in S. cerevisiae.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology journal"
DOI: 10.1002/biot.201600631
Abstract: Therapeutic protein production in yeast is a reality in industry with an untapped potential to expand to more complex proteins, such as full-length antibodies. Despite numerous engineering approaches, cellular limitations are preventing the use of… read more here.
Keywords: antibody; antibody secretion; plasma cells; yeast ... See more keywords
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201746934
Abstract: The TNF family cytokines B‐cell activating factor (BAFF) and a proliferation‐inducing ligand (APRIL) support plasma cell survival. It is known that inhibitors of BAFF only (BAFFR‐Fc) or BAFF and APRIL (TACI‐Fc) administered early enough in… read more here.
Keywords: plasma; taci; plasma cells; baff ... See more keywords
Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948144
Abstract: Antibody‐mediated diseases affect more than 10% of the human population. For most, no cure is available, particularly when the pathogenic antibodies are secreted by long‐lived plasma cells resistant to conventional immunosuppressive therapies. Current therapeutic approaches… read more here.
Keywords: depletion plasma; plasma cells; antibody; selective depletion ... See more keywords
Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3705
Abstract: Next to proinflammatory cytokines, autoimmunity has been identified as a key trigger for osteoclast activation and bone loss. IgG‐rheumatoid factor (IgG‐RF) immune complexes, which are present in patients with rheumatoid arthritis, were shown to boost… read more here.
Keywords: production; bone; plasma cells; bone loss ... See more keywords
Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24782
Abstract: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have… read more here.
Keywords: myeloma giant; multiple myeloma; plasma cells;
Purification and Immunophenotypic Characterization of Murine Plasma Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1237-8_3
Abstract: B cells are primarily known for their capacity to differentiate into antibody-secreting cells (ASCs). ASCs are usually viewed as terminally differentiated cells sharing a unique phenotype. However, it lately became evident that ASCs exist in… read more here.
Keywords: plasma; immunophenotypic characterization; purification immunophenotypic; plasma cells ... See more keywords
Imaging of Bone Marrow Plasma Cells and of Their Niches.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1425-9_14
Abstract: Decade-long survival of plasma cells in the bone marrow has long been a puzzling matter. To understand how plasma cells are maintained and supported by survival-niches to account for lifelong antibody production demands new intravital… read more here.
Keywords: plasma cells; plasma; imaging bone; bone marrow ... See more keywords
Are uterine natural killer and plasma cells in infertility patients associated with endometriosis, repeated implantation failure, or recurrent pregnancy loss?
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05679-z
Abstract: Infertility is a debilitating situation that millions of women around the world suffer from, but the causal relationship between infertility and endometriosis is still unclear. We hypothesize that the immune cell populations of uterine natural… read more here.
Keywords: endometriosis; uterine natural; unk cells; natural killer ... See more keywords
A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurology"
DOI: 10.1007/s00415-018-9140-0
Abstract: ObjectiveIn the present study, we analyzed the inflammatory profiles of brain tissues obtained from patients with progressive multifocal leukoencephalopathy (PML) due to John Cunningham (JC) virus infection to identify potential prognostic factors.MethodsThe study included seven… read more here.
Keywords: prognosis; group; progressive multifocal; multifocal leukoencephalopathy ... See more keywords