Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231582
Abstract: Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range. Inflammation may contribute to lesion development in these individuals, but the underlying mechanisms… read more here.
Keywords: plasma; def; plasma cholesterol; mice ... See more keywords
Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5 −/− mice, decreases plasma cholesterol and epididymal fat deposition
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.859681
Abstract: We previously showed that Fmo5 −/− mice exhibit a lean phenotype and slower metabolic ageing. Their characteristics include lower plasma glucose and cholesterol, greater glucose tolerance and insulin sensitivity, and a reduction in age-related weight… read more here.
Keywords: butanediol; treatment; plasma cholesterol; cholesterol ... See more keywords
Statins redux: A re-assessment of how statins lower plasma cholesterol
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Diabetes"
DOI: 10.4239/wjd.v8.i6.230
Abstract: Obesity associated dyslipidemia and its negative effects on the heart and blood vessels have emerged as a major healthcare challenge around the globe. The use of statins, potent inhibitors of hydroxyl-methyl glutaryl (HMG) Co-A reductase,… read more here.
Keywords: plasma cholesterol; statins lower; cholesterol; treated mice ... See more keywords
Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.82269
Abstract: PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor that… read more here.
Keywords: surf4fl alb; surf4; alb cre; mice ... See more keywords