Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1212
Abstract: A pharmacokinetic (PK) study and a bioequivalence (BE) study were conducted to investigate the PK characteristics and safety of lubiprostone in healthy Chinese subjects and to evaluate the BE between the test and the reference… read more here.
Keywords: single dose; state; chinese subjects; lubiprostone ... See more keywords
Evaluation of the Cytochrome P450 3A and P-glycoprotein Drug-Drug Interaction Potential of Futibatinib.
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DOI: 10.1002/cpdd.1259
Abstract: Futibatinib, a selective, irreversible fibroblast growth factor receptor 1-4 inhibitor, is being investigated for tumors harboring FGFR aberrations and was recently approved for the treatment of FGFR2 fusion/rearrangement-positive intrahepatic cholangiocarcinoma. In vitro studies identified cytochrome… read more here.
Keywords: cyp3a; plasma concentration; drug drug; cytochrome p450 ... See more keywords
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.648
Abstract: Plazomicin is an aminoglycoside that was engineered to overcome aminoglycoside‐modifying enzymes, which are the most common aminoglycoside resistance mechanism in Enterobacteriaceae. Because plazomicin is predominantly eliminated via renal pathways, an in vitro study was conducted… read more here.
Keywords: plasma concentration; metformin; time; healthy subjects ... See more keywords
Evaluation of the Pharmacokinetic Interaction Between Doravirine and Methadone
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.699
Abstract: Doravirine is a novel nonnucleoside reverse transcriptase inhibitor indicated for the treatment of HIV type 1 infection. A subset of people living with HIV receives methadone for the treatment of opioid addiction. The current study… read more here.
Keywords: doravirine; plasma concentration; doravirine methadone; methadone ... See more keywords
Application of a Backpropagation Artificial Neural Network in Predicting Plasma Concentration and Pharmacokinetic Parameters of Oral Single‐Dose Rosuvastatin in Healthy Subjects
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DOI: 10.1002/cpdd.809
Abstract: A backpropagation artificial neural network (BPANN) model was established for the prediction of the plasma concentration and pharmacokinetic parameters of rosuvastatin (RVST) in healthy subjects. The data (demographic characteristics and results of clinical laboratory tests)… read more here.
Keywords: plasma concentration; concentration pharmacokinetic; model; healthy subjects ... See more keywords
Population Pharmacokinetic Models for Direct Oral Anticoagulants: A Systematic Review and Clinical Appraisal Using Exposure Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2649
Abstract: Available data have shown an association between direct oral anticoagulant (DOAC) plasma concentration and clinical, particularly bleeding, events. Factors that may influence DOAC plasma concentration are therefore the focus of particular attention. Population pharmacokinetic (PopPK)… read more here.
Keywords: plasma concentration; population pharmacokinetic; direct oral; doac plasma ... See more keywords
Correlation between pharmacokinetic parameters of 5-fluorouracil and related metabolites and adverse reactions in East-Asian patients with advanced colorectal cancer
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DOI: 10.1007/s00280-021-04387-y
Abstract: To examine the range of the area under the concentration–time curve (AUC) calculated using plasma 5-FU concentration at steady-state plasma concentration–time of 5-fluorouracil (5-FU) and correlation between 5-FU metabolites (5,6-dihydro-5-fluorouracil, 5-FUH2 and α-fluoro-β-Alanine, FBAL) plasma… read more here.
Keywords: cancer; correlation; auc; concentration ... See more keywords
Lisdexamfetamine Pharmacokinetic Comparison Between Patients Who Underwent Roux-en-Y Gastric Bypass and Nonsurgical Controls
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DOI: 10.1007/s11695-020-04969-4
Abstract: The objective of this research was to characterize the impact of Roux-en-Y gastric bypass (RYGB) on the pharmacokinetic properties of the pro-drug lisdexamfetamine and its active metabolite, d-amphetamine. A case-control design was used where patients… read more here.
Keywords: gastric bypass; plasma concentration; nonsurgical controls; lisdexamfetamine ... See more keywords
Evaluation of the Pharmacokinetics and Pharmacodynamics of Prasugrel in Japanese Elderly Subjects
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DOI: 10.1007/s40261-017-0525-0
Abstract: Background and ObjectiveAn increased incidence in bleeding events has been reported in Western elderly patients receiving prasugrel. Therefore, doses in Japanese elderly subjects need to be carefully determined. We assessed the pharmacokinetic and pharmacodynamic effects… read more here.
Keywords: plasma concentration; elderly subjects; maintenance dose; japanese elderly ... See more keywords
Increased dabigatran plasma concentration during Ibrutinib treatment: a case of cerebral hemorrhage and successful dabigatran reversal by idarucizumab
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DOI: 10.1007/s40520-017-0752-5
Abstract: to receive Ibrutinib are elderly and are likely to require anticoagulant or antiplatelet therapy owing to associated comorbidities, including atrial fibrillation and ischemic diseases. Besides, due to the multiple interactions of Ibrutinib with several TKs… read more here.
Keywords: plasma concentration; ibrutinib; increased dabigatran; dabigatran ... See more keywords
Effect of lipid emulsion infusion on paliperidone pharmacokinetics in the acute overdose rat model: A potential emergency treatment for paliperidone intoxication
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.08.010
Abstract: &NA; Paliperidone prolongs cardiac repolarization in a concentration‐dependent manner. Meanwhile, continuous infusion of intravenous lipid emulsion (ILE) has been established as a detoxification therapy for lipophilic drugs. However, this change in pharmacokinetics of various drugs… read more here.
Keywords: plasma concentration; continuous infusion; infusion; lipid emulsion ... See more keywords