Relationship of Edoxaban Plasma Concentration and Blood Coagulation in Healthy Volunteers Using Standard Laboratory Tests and Viscoelastic Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1758
Abstract: The capability of viscoelastic measurement parameters to screen anticoagulation activity of edoxaban in relation to its plasma concentrations was evaluated in 15 healthy male volunteers. Blood samples were drawn before the oral administration of edoxaban… read more here.
Keywords: coagulation; plasma; edoxaban plasma; plasma concentrations ... See more keywords
Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.03.061
Abstract: Direct oral anticoagulants (DOACs) are first-line drugs used for the treatment of venous thromboembolism and prevention of stroke in patients with atrial fibrillation. These drugs do not require the regular biochemical monitoring that is mandatory… read more here.
Keywords: plasma concentrations; review; direct oral; chromatographic methods ... See more keywords
Natriuretic Peptide Plasma Concentrations and Risk of Cardiovascular Versus Non-Cardiovascular Events in Heart Failure with Reduced Ejection Fraction Insights from the PARADIGM-HF and ATMOSPHERE Trials.
Sign Up to like & getrecommendations! Published in 2021 at "American heart journal"
DOI: 10.1016/j.ahj.2021.02.015
Abstract: BACKGROUND N-terminal pro-B-type natriuretic peptide (NTproBNP) plasma concentrations are independent prognostic markers in patients with heart failure with reduced ejection fraction (HFrEF). Whether a differential risk association between NTproBNP plasma concentrations and risk of cardiovascular… read more here.
Keywords: natriuretic peptide; plasma concentrations; versus non; heart failure ... See more keywords
Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2018.09.003
Abstract: This study aimed to elucidate the impact of OATP1B1 genotype (*1b/*1b, *1b/*15, and *15/*15) on plasma concentrations of endogenous OATP1B1 substrates. Healthy volunteers with OATP1B1 *1b/*1b (n = 10), *1b/*15 (n = 7), or *15/*15 (n = 2) received oral administration… read more here.
Keywords: plasma concentrations; concentrations endogenous; healthy volunteers; endogenous oatp1b1 ... See more keywords
Decreased tacrolimus plasma concentrations during HCV therapy: a drug-drug interaction or is there an alternative explanation?
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2016.12.004
Abstract: Chronic hepatitis C virus (HCV) infection can cause severe liver cirrhosis, for which liver transplantation is the only therapy. To prevent organ rejection, transplanted patients are treated with immunosuppressive agents. We describe two transplanted patients… read more here.
Keywords: hcv therapy; tacrolimus plasma; plasma concentrations; hcv infection ... See more keywords
An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.06.015
Abstract: Though marketed for over half a century, little is known about the pharmacokinetics of oral vancomycin except that its bioavailability is low, thus making accurate determination of plasma concentrations difficult. To quantify plasma concentrations of… read more here.
Keywords: vancomycin; plasma; plasma concentrations; quantification ... See more keywords
Effects of intermittent fasting diets on plasma concentrations of inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2020 at "Nutrition"
DOI: 10.1016/j.nut.2020.110974
Abstract: Intermittent fasting (IF) and energy-restricted diets (ERDs) have emerged as dietary approaches to decrease inflammatory status; however, there are no consistent results regarding humans. To achieve a comprehensive conclusion, we aimed to conduct a meta-analysis… read more here.
Keywords: analysis; plasma concentrations; intermittent fasting; analysis randomized ... See more keywords
Prediction of Plasma Concentrations Using In Silico Modelling and Simulation Approach: Case of Acebutolol.
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DOI: 10.1016/j.pharma.2021.02.004
Abstract: PURPOSE The aim of this study was to predict the plasma concentrations of acebutolol tablets with different dissolution profiles using computer modelling and evaluating whether they are bioequivalent using simulated population studies. METHODS The dissolution… read more here.
Keywords: plasma concentrations; prediction plasma; using silico; concentrations using ... See more keywords
A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo-fetal development studies.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2019.02.004
Abstract: Predicting embryotoxicity of pharmaceutical compounds or industrial chemicals is crucial for public safety. Conventional studies which monitor embryo-fetal development in rats and rabbits are costly and time consuming. Alternative assays which are simpler and less… read more here.
Keywords: plasma; plasma concentrations; embryo fetal; assay ... See more keywords
Effect of smoking on risperidone pharmacokinetics – A multifactorial approach to better predict the influence on drug metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2016.12.016
Abstract: PURPOSE To disentangle an association between tobacco smoking, smoking habits and pharmacokinetic patterns such as plasma concentrations of risperidone (RIS), its active metabolite 9-hydroxyrisperidone (9-OH-RIS) and the active moiety, AM, (RIS+9-OH-RIS) in a naturalistic sample.… read more here.
Keywords: smoking risperidone; effect smoking; plasma concentrations; ris ... See more keywords
Relationship between circulating progesterone at timed-AI and fertility in dairy cows subjected to GnRH-based protocols.
Sign Up to like & getrecommendations! Published in 2017 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2017.02.004
Abstract: The objectives of this retrospective study were: 1) to investigate the effect of plasma progesterone (P4) concentrations at the time of timed-AI (TAI) on fertility, and 2) to examine risk factors associated with plasma P4… read more here.
Keywords: cows subjected; gnrh based; plasma concentrations; dairy cows ... See more keywords