Plasma contact factors as therapeutic targets.
Sign Up to like & getrecommendations! Published in 2018 at "Blood reviews"
DOI: 10.1016/j.blre.2018.04.001
Abstract: Direct oral anticoagulants (DOACs) are small molecule inhibitors of the coagulation proteases thrombin and factor Xa that demonstrate comparable efficacy to warfarin for several common indications, while causing less serious bleeding. However, because their targets… read more here.
Keywords: therapeutic targets; contact factors; factors therapeutic; plasma contact ... See more keywords
Plasma contact activation by a fucosylated chondroitin sulfate and its structure–activity relationship study
Sign Up to like & getrecommendations! Published in 2018 at "Glycobiology"
DOI: 10.1093/glycob/cwy067
Abstract: Plasma contact system is the initial part of both the intrinsic coagulation pathway and kallikrein-kinin pathway, which mainly involves three proteins: coagulation factor XII (FXII), prekallikrein (PK) and high-molecular weight kininogen. Fucosylated chondroitin sulfate (FCS)… read more here.
Keywords: plasma contact; contact activation; activation; chondroitin sulfate ... See more keywords
Vascular Dysfunction in Alzheimer’s Disease: Alterations in the Plasma Contact and Fibrinolytic Systems
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087046
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting millions of people worldwide. The classical hallmarks of AD include extracellular beta-amyloid (Aβ) plaques and neurofibrillary tau tangles, although they are often accompanied by various… read more here.
Keywords: alterations plasma; vascular dysfunction; disease; alzheimer disease ... See more keywords