Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13357
Abstract: Brain metastasis (BM) genetically diverges from the primary tumor in non‐small‐cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for the delivery of targeted therapies. Circulating tumor DNA (ctDNA) sequencing has emerged… read more here.
Keywords: ctdna; plasma ctdna; brain; tumor ... See more keywords
Circulating tumor DNA is a prognostic biomarker in metastatic melanoma patients treated with chemoimmunotherapy and BRAF inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Acta Oncologica"
DOI: 10.1080/0284186x.2022.2137693
Abstract: Abstract Background Detectable circulating tumor DNA (ctDNA) has been associated with worse prognosis in melanoma patients. Material and methods We studied plasma ctDNA as a prognostic biomarker in 19 patients with metastatic melanoma and a… read more here.
Keywords: ctdna; plasma ctdna; melanoma patients; metastatic melanoma ... See more keywords
Plasma ctDNA monitoring during epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor treatment in patients with EGFR-mutant non-small cell lung cancer (JP-CLEAR trial)
Sign Up to like & getrecommendations! Published in 2019 at "Japanese Journal of Clinical Oncology"
DOI: 10.1093/jjco/hyz023
Abstract: ctDNA monitoring during EGFR-TKI treatment is useful for detecting T790M mutation. However, the efficacy of osimertinib treatment based on T790M status in plasma ctDNA remains to be established. read more here.
Keywords: ctdna; plasma ctdna; ctdna monitoring; treatment ... See more keywords
GENE-01. THE MUTATIONAL LANDSCAPE OF PRIMARY CHORDOMAS AND THEIR SENSITIVE DETECTION IN PLASMA ctDNA BY MULTIPLE NEXT GENERATION SEQUENCING TECHNOLOGIES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.403
Abstract: CNS-associated tumors are notoriously difficult to detect in plasma. Chordomas are the most common primary spinal column malignancy, and extensive surgical procedures, along with chemotherapy and radiation are required to reduce recurrence. Currently CT, MRI,… read more here.
Keywords: mutational landscape; ctdna; detection; biopsy ... See more keywords
Detecting T790M mutation of tissue and plasma ctDNA samples by ARMS in EGFR-mutant NSCLC patients after disease progression.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e20625
Abstract: e20625Background: T790M mutation is the most common mechanism of acquired EGFR TKI resistance. The use of T790M-targeted EGFR TKIs needs re-biopsy to confirm the existence of sensitive mutation. Pe... read more here.
Keywords: tissue plasma; detecting t790m; plasma ctdna; t790m mutation ... See more keywords