Multiple Epitopes of Hepatitis B Virus Surface Antigen Targeted by Human Plasma-derived Immunoglobulins Coincide with Clinically Observed Escape Mutations.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27278
Abstract: Hepatitis B Immune Globulin (HBIG) is a human plasma-derived IgG concentrate that contains a high titer of neutralizing antibodies (anti-HBs) to the hepatitis B virus (HBV) surface antigen (HBsAg). HBIG is known to be highly… read more here.
Keywords: surface antigen; human plasma; anti hbs; site ... See more keywords
α‐Synuclein in Plasma‐Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders"
DOI: 10.1002/mds.28639
Abstract: Extracellular vesicles are small vesicles that are released from many cells, including neurons. α‐Synuclein has recently been described in extracellular vesicles derived from the central nervous system and may contribute to the spreading of disease… read more here.
Keywords: extracellular vesicles; vesicles potential; derived extracellular; synuclein plasma ... See more keywords
Autologous fibrin scaffolds: When platelet- and plasma-derived biomolecules meet fibrin.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.11.029
Abstract: The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting as part of biological defense system leading to the formation of a fibrin clot in which activated platelets are trapped to quickly stop… read more here.
Keywords: platelet plasma; plasma derived; fibrin scaffolds; tissue ... See more keywords
PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103253
Abstract: Background Congenital malformations are common birth defects with high neonatal morbidity and mortality. It is essential to find simpler and more efficient biomarkers for early prenatal diagnosis. Therefore, we investigated PIWI-interacting RNAs (piRNAs) as potential… read more here.
Keywords: piwi interacting; biomarkers early; women carrying; normal foetuses ... See more keywords
Plasma‐derived exosomes contribute to inflammation via the TLR9‐NF‐&kgr;B pathway in chronic heart failure patients
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.03.011
Abstract: HighlightsPlasma‐derived exosomes carried mtDNA.Exosomes contribute to inflammation through the mtDNA‐TLR9‐NF‐&kgr;B pathway.Chloroquine can block this pathway. Abstract Exosomes are small vesicles that contain proteins, DNA and RNA, and play an important role in inflammation; however, the… read more here.
Keywords: kgr pathway; inflammation; tlr9 kgr; plasma derived ... See more keywords
THE SAFETY AND TOLERABILITY OF MULTIPLE DOSE ADMINISTRATION OF CSL112, AN INTRAVENOUS FORMULATION OF PLASMA-DERIVED APOA-I, AMONG SUBJECTS WITH MODERATE RENAL IMPAIRMENT AFTER ACUTE MYOCARDIAL INFARCTION
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)30706-x
Abstract: CSL112 is plasma-derived apolipoprotein A-I (apoA-I), currently in development for early reduction of cardiovascular risk after acute myocardial infarction (AMI). The AEGIS-I trial demonstrated renal and hepatic safety and elevations in cholesterol efflux with 4… read more here.
Keywords: acute myocardial; myocardial infarction; plasma derived; safety ... See more keywords
Proteomic Analysis of Plasma-Derived Extracellular Vesicles in Smokers and Patients with Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b00966
Abstract: Circulating biomarkers using targeted approaches from human plasma-derived extracellular vesicles (EVs) in the pathobiology of chronic obstructive pulmonary disease (COPD) are an emerging tool. There are several challenges in the field of EV proteomics. We… read more here.
Keywords: chronic obstructive; derived extracellular; plasma derived; extracellular vesicles ... See more keywords
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16337-y
Abstract: Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of… read more here.
Keywords: extracellular vesicles; spleen fibroblasts; vivax patients; plasmodium vivax ... See more keywords
Validation of plasma-derived small extracellular vesicles as cancer biomarkers
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-00433-5
Abstract: A role for extracellular vesicles and particles (EVPs) as cancer biomarkers has been elusive. A mass spectrometry-based comparative analysis of EVPs from individuals with or without cancer has now enabled the identification of tumour-associated protein… read more here.
Keywords: extracellular vesicles; validation plasma; cancer; cancer biomarkers ... See more keywords
A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14264-5
Abstract: Extracellular vesicles (EVs) are key mediators of intercellular communication. Part of their biological effects can be attributed to the transfer of cargos of diverse types of RNAs, which are promising diagnostic and prognostic biomarkers. EVs… read more here.
Keywords: extracellular vesicles; total transcriptome; method; transcriptome profiling ... See more keywords
Cytochrome C oxidase Inhibition and Cold Plasma-derived Oxidants Synergize in Melanoma Cell Death Induction
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31031-2
Abstract: Despite striking advances in the treatment of metastasized melanoma, the disease is often still fatal. Attention is therefore paid towards combinational regimens. Oxidants endogenously produced in mitochondria are currently targeted in pre-clinical and clinical studies.… read more here.
Keywords: melanoma cell; cco; cytochrome oxidase; inhibition ... See more keywords