Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1815031116
Abstract: Significance Circulating DNA in plasma has many diagnostic applications, including noninvasive prenatal testing and cancer liquid biopsy. Plasma DNA consists of short fragments of DNA. However, there is little information about mechanisms that are involved… read more here.
Keywords: plasma dna; dna; deletion; fragmentation ... See more keywords
Androgen receptor gene status in plasma DNA associates with worse outcome on enzalutamide or abiraterone for castration-resistant prostate cancer: a multi-institution correlative biomarker study
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx155
Abstract: Abstract Background There is an urgent need to identify biomarkers to guide personalized therapy in castration-resistant prostate cancer (CRPC). We aimed to clinically qualify androgen receptor (AR) gene status measurement in plasma DNA using multiplex… read more here.
Keywords: status; plasma; plasma dna; enzalutamide abiraterone ... See more keywords
Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvac050
Abstract: BACKGROUND Jagged ends of plasma DNA are a recently recognized class of fragmentomic markers for cell-free DNA, reflecting the activity of nucleases. A number of recent studies have also highlighted the importance of jagged ends… read more here.
Keywords: dna; lupus erythematosus; systemic lupus; jagged ends ... See more keywords
Post‐cardiac arrest level of free‐plasma DNA and DNA‐histone complexes
Sign Up to like & getrecommendations! Published in 2017 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.12882
Abstract: Plasma DNA‐histone complexes and total free‐plasma DNA have the potential to quantify the ischaemia‐reperfusion damages occurring after cardiac arrest. Furthermore, DNA‐histone complexes may have the potential of being a target for future treatment. The aim… read more here.
Keywords: histone complexes; plasma dna; dna histone; dna ... See more keywords
Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/7371403
Abstract: Background. Cardiovascular autonomic dysfunction is well known in Parkinson's disease (PD) presentation and it produces hypoperfusion of vital organs. The association between cardiovascular autonomic dysfunction and oxidative stress was examined in previous animal models. Oxidative… read more here.
Keywords: plasma dna; white matter; dna; parkinson disease ... See more keywords
Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/4034509
Abstract: Background Parkinson's disease (PD) is a common neurodegenerative disease associated with accumulation of misfolding proteins and increased neuroinflammation, which may further impair the glymphatic system. The purpose of this study was to utilize diffusion tensor… read more here.
Keywords: alps index; perivascular space; plasma dna; along perivascular ... See more keywords