A large‐scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5442
Abstract: The pathogenesis of cancers depends on the molecular background of each individual patient. Therefore, verifying as many biomarkers as possible and clarifying their relationships with each disease status would be very valuable. We performed a… read more here.
Keywords: plasma extracellular; extracellular vesicles; large scale; scale targeted ... See more keywords
Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-19223-z
Abstract: Protein biomarkers from plasma extracellular vesicles (EVs) have been extensively identified in various diseases. To explore biomarkers associated with diabetic retinopathy (DR) progression, we designed two cohorts, discovery and validation cohorts, including four groups: healthy… read more here.
Keywords: progression; plasma extracellular; protein biomarkers; cela3a cela3b ... See more keywords
Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet’s disease severity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Extracellular Vesicles"
DOI: 10.1080/20013078.2017.1284449
Abstract: ABSTRACT Behçet’s disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived antimicrobial peptide LL37… read more here.
Keywords: extracellular vesicles; vesicles immune; plasma extracellular; pathology ... See more keywords
#452 Plasma extracellular cold-inducible RNA-binding protein (eCIRP) is associated with acute kidney injury in patients after cardiac arrest
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.0944
Abstract: Acute kidney injury (AKI) is a predictor of mortality after a resuscitated cardiac arrest (CA). We aimed to evaluate plasma extracellular cold-induced RNA-binding protein (eCIRP), a pro-inflammatory alarmin released in metabolic stress situations, in predicting… read more here.
Keywords: plasma extracellular; extracellular cold; cardiac arrest; kidney injury ... See more keywords
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13754
Abstract: Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of aging‐associated neurological disorders. Experimental therapies aimed at boosting brain NAD+ levels… read more here.
Keywords: plasma extracellular; extracellular vesicles; pathology; vesicles enriched ... See more keywords
Altered non‐coding RNA profiles of seminal plasma extracellular vesicles of men with poor semen quality undergoing in vitro fertilization treatment
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13295
Abstract: Currently, the precise mechanisms that underline male infertility are still unclear. Accumulating data implicate non‐coding RNA cargo of seminal plasma extracellular vesicles due to their association with poor semen quality and higher expression levels relative… read more here.
Keywords: plasma extracellular; extracellular vesicles; non coding; plasma ... See more keywords
Plasma extracellular nanovesicle (exosome)‐derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13793
Abstract: Demonstrate the presence of cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT) proteins and mRNAs in isolated human plasma exosomes and evaluate the capacity for exosome‐derived biomarkers to characterize variability in CYP3A4 activity. read more here.
Keywords: characterize variability; plasma extracellular; drug; derived biomarkers ... See more keywords
The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adl2256
Abstract: The impact of cerebral malaria on the transcriptional profiles of cerebral tissues is difficult to study using noninvasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and community controls and sequenced… read more here.
Keywords: extracellular vesicles; brain; mrna content; cerebral malaria ... See more keywords
A standardized method for plasma extracellular vesicle isolation and size distribution analysis
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0284875
Abstract: The following protocol describes our workflow for isolation and quantification of plasma extracellular vesicles (EVs). It requires limited sample volume so that the scientific value of specimens is maximized. These steps include isolation of vesicles… read more here.
Keywords: plasma extracellular; size distribution; isolation; size ... See more keywords
Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4+ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p Transfer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.697604
Abstract: HIV latency is a challenge to the success of antiretroviral therapy (ART). Hence patients may benefit from interventions that efficiently reactivate the latent virus to be eliminated by ARTs. Here we show that plasma extracellular… read more here.
Keywords: extracellular vesicles; hiv infection; mir 139; enhance hiv ... See more keywords
Expression Pattern of Seminal Plasma Extracellular Vesicle Small RNAs in Boar Semen
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.585276
Abstract: Extracellular vesicles (EVs) regulate multiple physiological processes. Seminal plasma contains numerous EVs that may deliver functional molecules such as small RNAs (sRNAs) to the sperm. However, the RNA profiles in the boar seminal plasma extracellular… read more here.
Keywords: total reads; plasma extracellular; seminal plasma; small rnas ... See more keywords