Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01330-w
Abstract: Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies demonstrate reduced pGSN concentrations in several disease states, including severe trauma, burns, and… read more here.
Keywords: cgd patients; pgsn; plasma gelsolin; healthy volunteers ... See more keywords
Delayed Therapy with Plasma Gelsolin Improves Survival in Murine Pneumococcal Pneumonia
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx163.1215
Abstract: Abstract Background Innate immune responses contribute to successful resolution of bacterial pneumonia. Bolstering host defense with immunomodulators might be increasingly needed to improve outcomes in antibiotic-resistant infections. One candidate molecule is recombinant human plasma gelsolin… read more here.
Keywords: plasma gelsolin; pgsn; rhu pgsn; pneumonia ... See more keywords
Plasma Gelsolin Enhances Phagocytosis of Candida auris by Human Neutrophils through Scavenger Receptor Class B
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DOI: 10.1128/spectrum.04082-22
Abstract: The incidence of life-threatening multidrug-resistant Candida auris infections is rapidly growing, causing substantial economic costs due to outbreaks in hospital wards. Primary and secondary immunodeficiencies in susceptible individuals, such as those with leukemia, solid organ… read more here.
Keywords: auris; plasma gelsolin; phagocytosis; candida auris ... See more keywords
Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomes
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DOI: 10.3389/fimmu.2022.1011084
Abstract: Background Prognostic markers for COVID-19 disease outcome are currently lacking. Plasma gelsolin (pGSN) is an actin-binding protein and an innate immune marker involved in disease pathogenesis and viral infections. Here, we demonstrate the utility of… read more here.
Keywords: predict covid; covid severity; covid; pgsn ... See more keywords
Plasma Gelsolin Reinforces the Diagnostic Value of FGF-21 and GDF-15 for Mitochondrial Disorders
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DOI: 10.3390/ijms22126396
Abstract: Mitochondrial disorders (MD) comprise a group of heterogeneous clinical disorders for which non-invasive diagnosis remains a challenge. Two protein biomarkers have so far emerged for MD detection, FGF-21 and GDF-15, but the identification of additional… read more here.
Keywords: plasma gelsolin; fgf; mitochondrial disorders; pgsn ... See more keywords