A Western-style diet interacts with genetic variants of the LDL receptor to hyper-LDL cholesterolemia in Korean adults
Sign Up to like & getrecommendations! Published in 2020 at "Public Health Nutrition"
DOI: 10.1017/s1368980020001305
Abstract: Abstract Objective: To evaluate the association of genetic risk scores (GRS) of LDLR, APOB and proprotein convertase subtilisin-kexin type 9 (PCSK9) SNP and plasma LDL concentrations and to identify lifestyle interactions with the GRS in… read more here.
Keywords: style; genetic variants; ldl concentrations; western style ... See more keywords
RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321938
Abstract: Background: Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking. Increasing the availability of hepatic LDL receptors (LDLRs) remains a major clinical target for reducing… read more here.
Keywords: availability; hepatic ldlr; plasma ldl; rnf130 ... See more keywords
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.126462
Abstract: The evolutionary conserved Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex is one of the crucial multiprotein complexes that facilitates endosomal recycling of transmembrane proteins. Defects in WASH components have been associated with inherited developmental… read more here.
Keywords: hepatic wash; hdl cholesterol; wash complex; cholesterol ... See more keywords