Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3–IR and GM1–TrkA interactions
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14532
Abstract: The interactions between gangliosides and proteins belonging to the same or different lipid domains and their influence on physiological and pathological states have been analysed in detail. A well‐known factor impacting on lipid–protein interactions and… read more here.
Keywords: gm1 trka; signal transduction; gm1; regulation signal ... See more keywords
Terahertz Spectroscopy Sheds Light on Real-Time Exchange Kinetics Occurring through Plasma Membrane during Photodynamic Therapy Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300589
Abstract: Methods to follow in real time complex processes occurring along living cell membranes such as cell permeabilization are rare. Here, the terahertz spectroscopy reveals early events in plasma membrane alteration generated during photodynamic therapy (PDT)… read more here.
Keywords: spectroscopy; terahertz spectroscopy; real time; plasma membrane ... See more keywords
A Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202305934
Abstract: The Gasdermin protein is a membrane disruptor that can mediate immunogenic pyroptosis and elicit anti‐tumor immune function. However, cancer cells downregulate Gasdermin and develop membrane repair mechanisms to resist pyroptosis. Therefore, an artificial membrane disruptor… read more here.
Keywords: membrane rupture; tumor; immune; membrane ... See more keywords
Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406473
Abstract: Candidiasis, which presents a substantial risk to human well‐being, is frequently treated with azoles. However, drug‐drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, represent… read more here.
Keywords: cytotoxic autophagy; membrane localization; ergosterol; drug ... See more keywords
Composition and abundance of midgut plasma membrane proteins in two major hemipteran vectors of plant viruses, Bemisia tabaci and Myzus persicae.
Sign Up to like & getrecommendations! Published in 2024 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.22133
Abstract: Multiple species within the order Hemiptera cause severe agricultural losses on a global scale. Aphids and whiteflies are of particular importance due to their role as vectors for hundreds of plant viruses, many of which… read more here.
Keywords: persicae; plant; physiology; membrane ... See more keywords
Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500327
Abstract: Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing… read more here.
Keywords: biology; platform; development; plasma membrane ... See more keywords
Simultaneous co-overexpression of Saccharomyces cerevisiae septins Cdc3 and Cdc10 drives pervasive, phospholipid-, and tag-dependent plasma membrane localization.
Sign Up to like & getrecommendations! Published in 2023 at "Cytoskeleton"
DOI: 10.1002/cm.21762
Abstract: Septin proteins contribute to many eukaryotic processes involving cellular membranes. In the budding yeast Saccharomyces cerevisiae, septin hetero-oligomers interact with the plasma membrane (PM) almost exclusively at the future site of cytokinesis. While multiple mechanisms… read more here.
Keywords: localization; septins cdc3; septin; cdc3 cdc10 ... See more keywords
LEGO‐Inspired Drug Design: Unveiling a Class of Benzo[d]thiazoles Containing a 3,4‐Dihydroxyphenyl Moiety as Plasma Membrane H+‐ATPase Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700635
Abstract: The fungal plasma membrane H+‐ATPase (Pma1p) is a potential target for the discovery of new antifungal agents. Surprisingly, no structure–activity relationship studies for small molecules targeting Pma1p have been reported. Herein, we disclose a LEGO‐inspired… read more here.
Keywords: benzo; dihydroxyphenyl; plasma membrane; membrane atpase ... See more keywords
Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30772
Abstract: Organic anion transport proteins (OATPs) on the basolateral surface of hepatocytes mediate uptake of a number of drugs and endogenous compounds. Previous studies showed that rat OATP1A1 (rOATP1A1) has a postsynaptic density protein, drosophila disc… read more here.
Keywords: anion transport; plasma membrane; roatp1a1; organic anion ... See more keywords
Structure and function of yeast and fungal Na+/H+ antiporters
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1701
Abstract: Sodium proton antiporters (or sodium proton exchangers [NHEs]) are a critical family of membrane proteins that exchange sodium for protons across cell membranes. In yeast and plants, their primary function is to keep the sodium… read more here.
Keywords: fungal antiporters; function yeast; plasma membrane; function ... See more keywords
Label‐free surface‐enhanced Raman spectroscopy of lipid‐rafts from hepatocyte plasma membranes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.5101
Abstract: Lipid rafts are sphingomyelin/cholesterol-rich domains present in the plasma membrane of eukaryotic cells. In the hepatocyte, it has been shown that these domains intervene and modify a wide range of functions from which cell signaling… read more here.
Keywords: surface enhanced; spectroscopy; raman spectroscopy; lipid rafts ... See more keywords