Untargeted plasma metabolomics for risk prediction of hepatocellular carcinoma: A prospective study in two Chinese cohorts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34229
Abstract: Characterization of metabolic perturbation prior to hepatocellular carcinoma (HCC) may deepen the understanding of causal pathways and identify novel biomarkers for early prevention. We conducted two 1:1 matched nested case‐control studies (108 and 55 pairs)… read more here.
Keywords: hepatocellular carcinoma; plasma metabolomics; hcc risk; risk ... See more keywords
Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.02.013
Abstract: ALDH16A1 is a novel member of the ALDH superfamily that is enzymatically-inactive and highly expressed in the kidney. Recent studies identified an association between a rare missense single nucleotide variant (SNV) in the ALDH16A1 gene… read more here.
Keywords: analysis; plasma metabolomics; analysis plasma; mice ... See more keywords
Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00884
Abstract: Hibernation is an evolutionary adaptation that affords some mammals the ability to exploit the cold to achieve extreme metabolic depression (torpor) while avoiding ischemia/reperfusion or hemorrhagic shock injuries. Hibernators cycle periodically out of torpor, restoring… read more here.
Keywords: ground; numb back; comfortably numb; plasma metabolomics ... See more keywords
Antiperspirant effects and mechanism investigation of Mulisan decoction in rats based on plasma metabolomics
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2074465
Abstract: Abstract Context Mulisan decoction (MLS) is a classic formula of traditional Chinese medicine for treating hyperhidrosis. The mechanism remains unclear. Objective To investigate the antiperspirant effect and underlying mechanisms of MLS. Materials and methods Fifty… read more here.
Keywords: plasma metabolomics; antiperspirant effects; antiperspirant effect; mulisan decoction ... See more keywords
Validation of a plasma metabolomics model that allows anticipation of the occurrence of cytomegalovirus DNAaemia in allogeneic stem cell transplant recipients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.000746
Abstract: A plasma metabolomic model obtained by means of untargeted 1H nuclear magnetic resonance, to which taurine, choline, methylamine, total glutathione, trimethylamine N-oxide, lactate, lysine, isoleucine, total fatty acids and unsaturated fatty acids contributed, was validated… read more here.
Keywords: plasma metabolomics; stem cell; dnaaemia; allogeneic stem ... See more keywords
Plasma metabolomics analysis in sickle cell disease patients with albuminuria – an exploratory study
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15592
Abstract: Chunsun Jiang* Chengfeng Bi* Xiaoxing Jiang Tian Tian Xin Huang Cheng Wang Mario R. Fernandez Javeed Iqbal Wing C. Chan Timothy W. McKeithan Robert E. Lewis Kai Fu Departments of Pathology and Microbiology, University of… read more here.
Keywords: medical center; plasma metabolomics; pathology; analysis sickle ... See more keywords
Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Circulation"
DOI: 10.1161/circulationaha.116.024602
Abstract: Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. Methods: We conducted a comprehensive study of plasma metabolites using ultraperformance liquid chromatography mass spectrometry to identify patients at high risk of early… read more here.
Keywords: arterial hypertension; plasma metabolomics; pulmonary arterial; control subjects ... See more keywords
Plasma Metabolomics of Acute Coronary Syndrome Patients Based on Untargeted Liquid Chromatography–Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.616081
Abstract: Background: Acute coronary syndrome (ACS) is the main cause of death and morbidity worldwide. The present study aims to investigate the altered metabolites in plasma from patients with ACS and sought to identify metabolic biomarkers… read more here.
Keywords: plasma metabolomics; acute coronary; untargeted liquid; based untargeted ... See more keywords
Integrated Analysis of the Cecal Microbiome and Plasma Metabolomics to Explore NaoMaiTong and Its Potential Role in Changing the Intestinal Flora and Their Metabolites in Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.773722
Abstract: Ischemic stroke (IS), as a leading cause of disability worldwide, affects intestinal bacterial communities and their metabolites, while recent discoveries have highlighted the importance of the intestinal microflora in the development of IS. Systematic investigations… read more here.
Keywords: plasma metabolomics; negatively correlated; metabolites ischemic; lachnospiraceae ucg ... See more keywords
Plasma Metabolomics Identifies the Dysregulated Metabolic Profile of Primary Immune Thrombocytopenia (ITP) Based on GC-MS
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.845275
Abstract: ITP is a common autoimmune bleeding disorder with elusive pathogenesis. Our study was implemented to profile the plasma metabolic alterations of patients diagnosed with ITP, aiming at exploring the potential novel biomarkers and partial mechanism… read more here.
Keywords: plasma metabolomics; itp patients; itp; metabolomics identifies ... See more keywords
Plasma Metabolomics and Machine Learning-Driven Novel Diagnostic Signature for Non-Alcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071669
Abstract: We performed targeted metabolomics with machine learning (ML)-based interpretation to identify metabolites that distinguish the progression of nonalcoholic fatty liver disease (NAFLD) in a cohort. Plasma metabolomics analysis was conducted in healthy control subjects (n… read more here.
Keywords: acid; metabolomics machine; machine learning; plasma metabolomics ... See more keywords