Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active‐Transporting of Liposome in Solid Tumor
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207271
Abstract: Ligand/receptor‐mediated targeted drug delivery has been widely recognized as a promising strategy for improving the clinical efficacy of nanomedicines but is attenuated by the binding of plasma protein on the surface of nanoparticles to form… read more here.
Keywords: plasma protein; ultrasonic cavitation; tumor; protein corona ... See more keywords
Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12738
Abstract: We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post‐traumatic seizures or neuromotor functional recovery (neuroscores), considering the effect of levetiracetam,… read more here.
Keywords: plasma protein; protein biomarkers; brain; early preclinical ... See more keywords
Predictive value of serum pregnancy‐associated plasma protein A for patients with ischemic cerebrovascular disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22091
Abstract: To investigate the role of pregnancy‐associated plasma protein A (PAPP‐A) in the outcome of ischemic cerebrovascular disease. read more here.
Keywords: ischemic cerebrovascular; plasma protein; cerebrovascular disease; associated plasma ... See more keywords
Pregnancy-associated plasma protein-A in atherosclerosis: Molecular marker, mechanistic insight, and therapeutic target.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.10.004
Abstract: Pregnancy-associated plasma protein-A (PAPP-A), a member of the metzincin metalloproteinase superfamily, can enhance local insulin-like growth factor (IGF) bioavailability through proteolytic cleavage of three IGF binding proteins. In patients with coronary atherosclerosis disease (CAD), elevated… read more here.
Keywords: associated plasma; plasma protein; atherosclerosis; pregnancy associated ... See more keywords
A novel strategy for prediction of human plasma protein binding using machine learning techniques
Sign Up to like & getrecommendations! Published in 2020 at "Chemometrics and Intelligent Laboratory Systems"
DOI: 10.1016/j.chemolab.2020.103962
Abstract: Abstract Plasma protein binding (PPB) is a key player of drug ADME (absorption, distribution, metabolism, elimination) behaviors, enabling PPB to have significant impact on drug efficacy and toxicity. As drug discovery enters the era of… read more here.
Keywords: protein binding; plasma protein; drug; prediction ... See more keywords
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103723
Abstract: Background COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying the various effects of the disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis of plasma protein profiles using… read more here.
Keywords: protein; covid patients; plasma protein; next generation ... See more keywords
Development and characterization of porcine plasma protein-chitosan blended films
Sign Up to like & getrecommendations! Published in 2019 at "Food Packaging and Shelf Life"
DOI: 10.1016/j.fpsl.2019.100406
Abstract: Abstract The effects were studied of porcine plasma protein (PPP) and chitosan (CS) on the properties of blended films. Blended film solutions of PPP (3% w/w)/CS (1% w/w) at different ratios (100PPP:0CS, 80PPP:20CS, 50PPP:50CS and… read more here.
Keywords: protein; ppp; plasma protein; film ... See more keywords
Rheological and nuclear magnetic resonance characterization of porcine plasma protein-stabilized gel-like emulsion affected by pH and heating
Sign Up to like & getrecommendations! Published in 2017 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2016.09.025
Abstract: Abstract In the present work, gel-like characteristics of porcine plasma protein oil-in-water (O/W; 52/48, g/100 g) emulsion has been studied under the influence of pH and heating. Viscosity analyses indicated that emulsions exhibited shear-thinning behaviors. Viscosity… read more here.
Keywords: gel like; plasma protein; like characteristics; porcine plasma ... See more keywords
Amyloid Protein-Biofunctionalized Polydopamine Nanoparticles Demonstrate Minimal Plasma Protein Fouling and Efficient Photothermal Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c00716
Abstract: Polydopamine (PDA) shows great application potential in photothermal therapy (PTT) of tumors due to its excellent photothermal performance. However, PDA rich in a large number of catechin structures, with strong adhesion, can readily attach to… read more here.
Keywords: plasma protein; pda tbsa; protein; pda ... See more keywords
Large-scale integration of the plasma proteome with genetics and disease.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00978-w
Abstract: The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations… read more here.
Keywords: plasma proteome; large scale; plasma protein; genetics ... See more keywords
Cremophor EL Alters the Plasma Protein Binding and Pharmacokinetic Profile of Valspodar in Rats.
Sign Up to like & getrecommendations! Published in 2017 at "Drug research"
DOI: 10.1055/s-0043-111411
Abstract: Cremophor EL is a nonionic surfactant widely used in pharmaceutical formulations. Nonetheless, there are several reports on the influence of this excipient on the protein binding, pharmacokinetics, and pharmacodynamics of drugs. Valspodar is an investigational… read more here.
Keywords: valspodar; protein binding; plasma protein; formulation ... See more keywords