Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading‐dependent changes linked to muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13146
Abstract: Inactivity and unloading induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the musculoskeletal system. It not only provides information for… read more here.
Keywords: plasma proteome; muscle; muscle atrophy; bed rest ... See more keywords
Integrated proteomic sample preparation with combination of on-line high-abundance protein depletion, denaturation, reduction, desalting and digestion to achieve high throughput plasma proteome quantification.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338343
Abstract: In this study, we developed an integrated plasma proteome sample preparation system, by which high-abundance proteins from human plasma were first depleted by immunoaffinity column, followed by on-line middle and low-abundance proteins denaturation, reduction, desalting… read more here.
Keywords: sample preparation; abundance; plasma proteome; preparation ... See more keywords
Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2018.11.017
Abstract: The etiology of adolescent idiopathic scoliosis (AIS), the most common rotational deformity of the spine, is still unclear. Emerging evidence suggests that gut microbiota dysbiosis influences musculoskeletal diseases such as arthritis and osteoporosis. However, the… read more here.
Keywords: plasma proteome; idiopathic scoliosis; plasma; adolescent idiopathic ... See more keywords
Synthesis of Surface-Functionalized Molybdenum Disulfide Nanomaterials for Efficient Adsorption and Deep Profiling of the Human Plasma Proteome by Data-Independent Acquisition.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02736
Abstract: Blood is one of the most important clinical samples for protein biomarker discovery, as it provides rich physiological and pathological information and is easy to obtain with low invasiveness. However, the discovery of protein biomarkers… read more here.
Keywords: surface functionalized; plasma proteome; synthesis; molybdenum disulfide ... See more keywords
Stability of the Human Plasma Proteome to Pre-Analytical Variability as Assessed by an Aptamer-Based Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00320
Abstract: Variable processing and storage of whole blood and/or plasma are potential confounders in biomarker development and clinical assays. The goal of the study was to investigate how pre-analytical variables impact the human plasma proteome. Whole… read more here.
Keywords: storage; plasma proteome; pre analytical; aptamer based ... See more keywords
Large-scale integration of the plasma proteome with genetics and disease.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00978-w
Abstract: The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations… read more here.
Keywords: plasma proteome; large scale; plasma protein; genetics ... See more keywords
Global chemical modifications comparison of human plasma proteome from two different age groups
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72196-z
Abstract: In this study, two groups of human plasma proteome at different age groups (old and young) were used to perform a comparison of global chemical modifications, as determined by tandem mass spectrometry (MS/MS) combined with… read more here.
Keywords: plasma proteome; age; human plasma; age groups ... See more keywords
An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123411119
Abstract: Significance Dietary fibers contain complex mixtures of biomolecules, making it difficult to develop/test hypotheses about how different fiber-types impact different components of the human gut microbiome and how microbiome changes that they produce are linked… read more here.
Keywords: plasma proteome; microbiome plasma; plasma; gut microbiome ... See more keywords
What can the plasma proteome tell us about platelets and (vice versa)?
Sign Up to like & getrecommendations! Published in 2023 at "Platelets"
DOI: 10.1080/09537104.2023.2186707
Abstract: Multi-omics approaches are being used increasingly to study physiological and pathophysiologic processes. Proteomics specifically focuses on the study of proteins as functional elements and key contributors to, and markers of the phenotype, as well as… read more here.
Keywords: plasma proteome; proteome tell; tell platelets; plasma platelet ... See more keywords
Plasma proteome dynamics of COVID-19 severity learnt by a graph convolutional network of multi-scale topology
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2022.07.04.498661
Abstract: We used a graph convolutional network to model the plasma proteome of 384 COVID-19 patients. The model incorporates clinical data and is able to predict severity. We identified the proteins that shifted most in expression… read more here.
Keywords: topology; graph convolutional; plasma proteome; severity ... See more keywords
Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long‐lived individuals
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13684
Abstract: The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well‐being and to possibly predict and/or avoid the development of age‐related disorders such as atherosclerosis and… read more here.
Keywords: lived individuals; plasma proteome; long lived; age ... See more keywords