Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading‐dependent changes linked to muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13146
Abstract: Inactivity and unloading induce skeletal muscle atrophy, loss of strength and detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the musculoskeletal system. It not only provides information for… read more here.
Keywords: plasma proteome; muscle; muscle atrophy; bed rest ... See more keywords
Integrated proteomic sample preparation with combination of on-line high-abundance protein depletion, denaturation, reduction, desalting and digestion to achieve high throughput plasma proteome quantification.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338343
Abstract: In this study, we developed an integrated plasma proteome sample preparation system, by which high-abundance proteins from human plasma were first depleted by immunoaffinity column, followed by on-line middle and low-abundance proteins denaturation, reduction, desalting… read more here.
Keywords: sample preparation; abundance; plasma proteome; preparation ... See more keywords
Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2018.11.017
Abstract: The etiology of adolescent idiopathic scoliosis (AIS), the most common rotational deformity of the spine, is still unclear. Emerging evidence suggests that gut microbiota dysbiosis influences musculoskeletal diseases such as arthritis and osteoporosis. However, the… read more here.
Keywords: plasma proteome; idiopathic scoliosis; plasma; adolescent idiopathic ... See more keywords
The plasma proteome of plant-based diets: analyses of 2920 proteins in 49,615 people from the UK Biobank
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the Nutrition Society"
DOI: 10.1017/s0029665125101018
Abstract: The investigation of proteomics, which describes the large-scale study of multiple proteins and their interconnected pathways, may enable a more comprehensive understanding of disease mechanisms due to the integral role of proteins in many biological… read more here.
Keywords: consumption; meat eaters; meat; plasma proteins ... See more keywords
Synthesis of Surface-Functionalized Molybdenum Disulfide Nanomaterials for Efficient Adsorption and Deep Profiling of the Human Plasma Proteome by Data-Independent Acquisition.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02736
Abstract: Blood is one of the most important clinical samples for protein biomarker discovery, as it provides rich physiological and pathological information and is easy to obtain with low invasiveness. However, the discovery of protein biomarkers… read more here.
Keywords: surface functionalized; plasma proteome; synthesis; molybdenum disulfide ... See more keywords
Stability of the Human Plasma Proteome to Pre-Analytical Variability as Assessed by an Aptamer-Based Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00320
Abstract: Variable processing and storage of whole blood and/or plasma are potential confounders in biomarker development and clinical assays. The goal of the study was to investigate how pre-analytical variables impact the human plasma proteome. Whole… read more here.
Keywords: storage; plasma proteome; pre analytical; aptamer based ... See more keywords
Dynamics of the blood plasma proteome during hyperacute HIV-1 infection
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54848-0
Abstract: The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from… read more here.
Keywords: hyperacute hiv; plasma proteome; infection; blood plasma ... See more keywords
Sex differences in the genetic regulation of the human plasma proteome
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59034-4
Abstract: Mechanisms underlying sex differences in the development and prognosis of many diseases remain largely elusive. Here, we systematically investigated sex differences in the genetic regulation of plasma proteome (>5800 protein targets) across two cohorts (30,307… read more here.
Keywords: differences genetic; sex differences; plasma proteome; sex ... See more keywords
Large-scale integration of the plasma proteome with genetics and disease.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00978-w
Abstract: The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations… read more here.
Keywords: plasma proteome; large scale; plasma protein; genetics ... See more keywords
Global chemical modifications comparison of human plasma proteome from two different age groups
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72196-z
Abstract: In this study, two groups of human plasma proteome at different age groups (old and young) were used to perform a comparison of global chemical modifications, as determined by tandem mass spectrometry (MS/MS) combined with… read more here.
Keywords: plasma proteome; age; human plasma; age groups ... See more keywords
Plasma proteome profiling reveals the therapeutic effects of the PPAR pan-agonist chiglitazar on insulin sensitivity, lipid metabolism, and inflammation in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-51210-8
Abstract: Chiglitazar is a novel peroxisome proliferator-activated receptor (PPAR) pan-agonist, which passed phase III clinical trials and was newly approved in China for use as an adjunct to diet and exercise in glycemic control in adult… read more here.
Keywords: plasma proteome; type diabetes; pan agonist; ppar pan ... See more keywords