Establishing Quality Control Procedures for Large-Scale Plasma Proteomics Analyses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.3c00050
Abstract: Proteomics research has been transformed due to high-throughput liquid chromatography (LC-MS/MS) tandem mass spectrometry instruments combined with highly sophisticated automated sample preparation and multiplexing workflows. However, scaling proteomics experiments to large sample cohorts (hundreds to… read more here.
Keywords: quality control; plasma proteomics; plasma; establishing quality ... See more keywords
Prioritizing Candidates of Post–Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.119.045158
Abstract: Supplemental Digital Content is available in the text. Background: Heart failure (HF) is the most common long-term complication of acute myocardial infarction (MI). Understanding plasma proteins associated with post-MI HF and their gene expression may… read more here.
Keywords: post; plasma proteins; cell; single cell ... See more keywords
Is Plasma Proteomics Able to Provide Alternative Paths to Better Understand Hypertension?
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09049
Abstract: See related article, pp 412–419 The history of hypertension research is sweet sour. Huge advances have been marred by the persistence of huge black boxes. The term primary hypertension epitomizes the issue: the underlying causes… read more here.
Keywords: hypertension plasma; able provide; plasma proteomics; proteomics able ... See more keywords
Correlation Between Plasma Proteomics and Adverse Outcomes Among Older Men With Chronic Coronary Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.867646
Abstract: Background Chronic coronary syndrome (CCS) is a newly proposed concept and is hallmarked by more long-term major adverse cardiovascular events (MACEs), calling for accurate prognostic biomarkers for initial risk stratification. Methods Data-independent acquisition liquid chromatography… read more here.
Keywords: coronary syndrome; events group; risk; chronic coronary ... See more keywords
Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1038086
Abstract: Severe injury is known to cause a systemic cytokine storm that is associated with adverse outcomes. However, a comprehensive assessment of the time-dependent changes in circulating levels of a broad spectrum of protein immune mediators… read more here.
Keywords: cytokine; immune mediators; injury; release ... See more keywords
Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies A Novel Proteomic Signature
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10010184
Abstract: Significant inter-individual variation in terms of susceptibility to several stress-related disorders, such as myocardial infarction and Alzheimer’s disease, and therapeutic response has been observed among healthy subjects. The molecular features responsible for this phenomenon have… read more here.
Keywords: signature; subjects differences; plasma; plasma proteomics ... See more keywords
Targeted Blood Plasma Proteomics and Hemostasis Assessment of Post COVID-19 Patients with Acute Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076523
Abstract: The molecular mechanisms underlying cardiovascular complications after the SARS-CoV-2 infection remain unknown. The goal of our study was to analyze the features of blood coagulation, platelet aggregation, and plasma proteomics in COVID-19 convalescents with AMI.… read more here.
Keywords: post; plasma proteomics; post covid; covid patients ... See more keywords
Challenges and Opportunities in Clinical Diagnostic Routine of Envenomation Using Blood Plasma Proteomics
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15030180
Abstract: Specific and sensitive tools for the diagnosis and monitoring of accidents by venomous animals are urgently needed. Several diagnostic and monitoring assays have been developed; however, they have not yet reached the clinic. This has… read more here.
Keywords: envenomation; routine; blood plasma; blood ... See more keywords