Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2590-y
Abstract: Bile acid prodrugs have served as a viable strategy for refining the pharmaceutical profile of parent drugs through utilizing bile acid transporters. A series of three ester prodrugs of the antiherpetic drug acyclovir (ACV) with… read more here.
Keywords: acv; hsv; plasma stability; antiviral activity ... See more keywords
Enhancing purification and plasma stability of porcine interferon-α/γ by fusion to elastin-like polypeptide.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2018.08.003
Abstract: The clinical use of recombinant interferons (rIFNs) is limited by higher purification cost and quick clearance from circulation. Elastin-like polypeptides (ELPs) are a novel tag for recombinant protein purification and half-life extension. In this study,… read more here.
Keywords: plasma stability; elp; fusion; purification ... See more keywords
A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine-Maleimide-Based Antibody Drug Conjugates.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b00694
Abstract: Plasma stability assessment under physiological temperature is an essential step for developing and optimizing antibody drug conjugate (ADC) molecules, especially those with cleavable linkers. The assessment of plasma stability often requires monitoring multiple analytes using… read more here.
Keywords: plasma stability; step; chemistry; drug ... See more keywords
Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01444
Abstract: Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas. Some hydroxamic acids display a high plasma clearance resulting in poor in vivo… read more here.
Keywords: toolbox; plasma stability; chemistry; hydroxamic acids ... See more keywords
Freeze‐dried plasma stability under prehospital field conditions
Sign Up to like & getrecommendations! Published in 2019 at "Transfusion"
DOI: 10.1111/trf.15533
Abstract: This study evaluated the effect of routine, uncontrolled, Israeli field storage conditions on the stability and efficacy of Lyo‐Plas N freeze‐dried plasma (FDP). We evaluated clotting factors V, VIII, and XI; proteins S and C;… read more here.
Keywords: dried plasma; plasma stability; field; freeze dried ... See more keywords
Advanced EPI-X4 Derivatives Covalently Bind Human Serum Albumin Resulting in Prolonged Plasma Stability
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315029
Abstract: Advanced derivatives of the Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) have shown therapeutic efficacy upon topical administration in animal models of asthma and dermatitis. Here, we studied the plasma stability of the EPI-X4 lead compounds… read more here.
Keywords: serum albumin; plasma stability; cxcr4; stability ... See more keywords