Analysis of Plasmalogen Synthesis in Cultured Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6937-1_6
Abstract: Plasmalogen synthesis can be analyzed by metabolic labeling, followed by the separation of ethanolamine plasmalogens from glycerophospholipids on one-dimensional thin-layer chromatography. The vinyl-ether bond of plasmalogens is acid-labile, which allows separating plasmalogens as 2-acyl-glycerophospholipids from… read more here.
Keywords: analysis plasmalogen; cultured cells; plasmalogen synthesis; synthesis cultured ... See more keywords
Oral Administration of Ethanolamine Glycerophospholipid Containing a High Level of Plasmalogen Improves Memory Impairment in Amyloid β-Infused Rats
Sign Up to like & getrecommendations! Published in 2017 at "Lipids"
DOI: 10.1007/s11745-017-4260-3
Abstract: Ethanolamine plasmalogen (PlsEtn), a major phospholipid in neuronal membranes [60–90 mol% of ethanolamine glycerophospholipid (EtnGpl)], is specifically decreased in brains from patients with Alzheimer’s disease (AD). The present study investigated how PlsEtn administration affects cognitive deficits… read more here.
Keywords: administration; ethanolamine glycerophospholipid; infused rats; plasmalogen ... See more keywords
Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.867138
Abstract: PPI-1011 is a synthetic plasmalogen precursor in development as a treatment for multiple plasmalogen-deficiency disorders. Previous work has demonstrated the ability of PPI-1011 to augment plasmalogens and its effects in vitro and in vivo, however,… read more here.
Keywords: plasmalogen; ppi; mass balance; ppi 1011 ... See more keywords
Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.884689
Abstract: Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond that endows them with unique physical-chemical properties. They have proposed biological roles in membrane organization, fluidity, signaling, and antioxidative functions, and abnormal plasmalogen levels correlate… read more here.
Keywords: desaturase; plasmalogen; desaturase peds1; plasmalogens photooxidative ... See more keywords
Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.912880
Abstract: Plasmalogens are plasma-borne antioxidant phospholipid species that provide protection as cellular lipid components during cellular oxidative stress. In this study we investigated plasma plasmalogen levels in human sepsis as well as in rodent models of… read more here.
Keywords: sepsis; infection; plasmalogen; plasma ... See more keywords
Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.946393
Abstract: Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical and biochemical features, but require specialized pathways of biosynthesis and metabolization. Recently, major advances have been made in our understanding of these… read more here.
Keywords: traffic; plasmalogen metabolism; regulation plasmalogen; plasmalogen ... See more keywords
Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01723
Abstract: Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play… read more here.
Keywords: membrane ethanolamine; phagocytosis; macrophages membrane; phagocytosis macrophages ... See more keywords
Plasmalogens and Chronic Inflammatory Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.730829
Abstract: It is becoming widely acknowledged that lipids play key roles in cellular function, regulating a variety of biological processes. Lately, a subclass of glycerophospholipids, namely plasmalogens, has received increased attention due to their association with… read more here.
Keywords: response; inflammatory diseases; inflammatory; chronic inflammatory ... See more keywords
Plasmalogens: Free Radical Reactivity and Identification of Trans Isomers Relevant to Biological Membranes
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050730
Abstract: Plasmalogens are membrane phospholipids with two fatty acid hydrocarbon chains linked to L-glycerol, one containing a characteristic cis-vinyl ether function and the other one being a polyunsaturated fatty acid (PUFA) residue linked through an acyl… read more here.
Keywords: plasmalogens free; plasmalogen; free radical; reactivity ... See more keywords