Contradictory to its effects on thrombin, C1-inhibitor reduces plasmin generation in the presence of thrombomodulin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01869-y
Abstract: C1-inhibitor (C1INH) was shown to enhance thrombin generation (TG) in the presence of thrombomodulin (TM) by reducing production of activated protein C. Because C1INH is known to inhibit fibrinolytic system proteases, the objective of this… read more here.
Keywords: presence; c1inh; presence thrombomodulin; plasmin generation ... See more keywords
A new assay to evaluate microvesicle plasmin generation capacity: validation in disease with fibrinolysis imbalance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Extracellular Vesicles"
DOI: 10.1080/20013078.2018.1494482
Abstract: ABSTRACT Among extracellular vesicles, leukocyte-derived microvesicles (LMVs) have emerged as complex vesicular structures. Primarily identified as procoagulant entities, they were more recently ascribed to plasmin generation capacity (MV-PGC). The objectives of this work were (1)… read more here.
Keywords: imbalance; plasmin generation; generation capacity; pgc ... See more keywords
Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15114
Abstract: Essentials Tranexamic acid (TXA) is an antifibrinolytic drug used to reduce bleeding. Assaying plasmin generation (PG) in plasma detects clinically relevant TXA levels in vitro and ex vivo. 3.1‐16.2 µg/mL TXA half‐maximally inhibits PG in… read more here.
Keywords: women undergoing; tranexamic acid; plasmin generation; cesarean delivery ... See more keywords
High fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019004267
Abstract: Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tools has left fibrinolytic mechanisms… read more here.
Keywords: hfd; fat diet; generation; plasmin generation ... See more keywords
Granulocyte microvesicles with a high plasmin generation capacity promote clot lysis and improve outcome in septic shock.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021013328
Abstract: Microvesicles (MVs) have previously been shown to exert profibrinolytic capacity, which is increased in patients with septic shock (SS) with a favorable outcome. We therefore hypothesized that the plasmin generation capacity (PGC) could confer to… read more here.
Keywords: generation capacity; capacity; plasmin generation; mvs ... See more keywords
The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.817305
Abstract: Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also… read more here.
Keywords: plasmin generation; vwf; thrombin plasmin; vwf adamts13 ... See more keywords