Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13396
Abstract: Recruitment of plasminogen is an important infection strategy of the human pathogen Streptococcus pneumoniae to invade host tissues. In Streptococcus aureus, triosephosphate isomerase (TPI) has been reported to bind plasminogen. In this study, the TPI of S. pneumoniae… read more here.
Keywords: autolysis binds; triosephosphate isomerase; pneumoniae; plasminogen ... See more keywords
Novel LRAP‐binding partner revealing the plasminogen activation system as a regulator of cementoblast differentiation and mineral nodule formation in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29331
Abstract: Amelogenin isoforms, including full‐length amelogenin (AMEL) and leucine‐rich amelogenin peptide (LRAP), are major components of the enamel matrix, and are considered as signaling molecules in epithelial–mesenchymal interactions regulating tooth development and periodontal regeneration. Nevertheless, the… read more here.
Keywords: nodule formation; plasminogen; amelogenin; mineral nodule ... See more keywords
The multifaceted role of plasminogen in inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2020.109761
Abstract: A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted to the serine protease plasmin, a key fibrinolytic factor by plasminogen… read more here.
Keywords: plasminogen; role plasminogen; inflammation; inflammatory response ... See more keywords
Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.08.029
Abstract: Abstract Background Tissue-type plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have been shown to be associated with increased risk for stroke, however, the association with incident atrial fibrillation (AF) is unknown. Methods We examined… read more here.
Keywords: plasminogen; activator inhibitor; prevend study; tissue ... See more keywords
Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.
Sign Up to like & getrecommendations! Published in 2019 at "Microbes and infection"
DOI: 10.1016/j.micinf.2019.04.004
Abstract: Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA)… read more here.
Keywords: plasminogen; infection; gas; role ... See more keywords
Inhibition of plasminogen/plasmin system retrieves endogenous nerve growth factor and adaptive spinal synaptic plasticity following peripheral nerve injury
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105113
Abstract: Dysfunctions of the neuronal-glial crosstalk and/or impaired signaling of neurotrophic factors represent key features of the maladaptive changes in the central nervous system (CNS) in neuroinflammatory as neurodegenerative disorders. Tissue plasminogen activator (tPA)/plasminogen (PA)/plasmin system… read more here.
Keywords: plasminogen plasmin; system; plasmin system; plasminogen ... See more keywords
Decreased circulating urokinase plasminogen activator receptor (uPAR) concentration in acute episodes of bipolar disorder; could it be a reflection of axonal injury?
Sign Up to like & getrecommendations! Published in 2018 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2018.02.009
Abstract: INTRODUCTION In recent years, the role of inflammation in the pathogenesis of Bipolar Disorder (BD) has been studied thoroughly. Urokinase-type plasminogen activator receptor (uPAR) is one of the molecules, whose concentration is of predictive value… read more here.
Keywords: state; serum soluble; soluble upar; plasminogen ... See more keywords
Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80010-z
Abstract: Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation and fibrinolysis will help inform… read more here.
Keywords: hospitalized covid; covid patients; plasminogen; activator inhibitor ... See more keywords
Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43028
Abstract: Because of high mortality caused by cardiovascular diseases, various fibrinolytic agents with diverse pharmacokinetic and pharmacodynamic properties have been developed. A novel mutated chimeric tissue plasminogen activator (mt-PA) was developed by the removal of first… read more here.
Keywords: chimeric tissue; plasminogen; novel mutated; plasminogen activator ... See more keywords
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214081120
Abstract: Triglyceride (TG) metabolism is highly regulated by angiopoietin-like protein (ANGPTL) family members [Y. Q. Chen et al., J. Lipid Res. 61, 1203-1220 (2020)]. During feeding, ANGPTL8 forms complexes with the fibrinogen-like domain-containing protein ANGPTL4 in adipose tissue… read more here.
Keywords: lpl activity; plasminogen; angptl4; plasmin ... See more keywords
Plasminogen-derived peptide promotes adipogenic differentiation of preadipocytes in vitro and in vivo
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DOI: 10.1080/21623945.2022.2149121
Abstract: ABSTRACT Soft tissue defects caused by adipose tissue loss can result in various conditions such as lipodystrophy in congenital diseases, trauma secondary to ageing, and mastectomy in breast cancer; fat grafting is commonly performed to… read more here.
Keywords: derived peptide; adipogenic differentiation; plasminogen; plasminogen derived ... See more keywords