A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13171
Abstract: Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver (PfPRL) is secreted and is an… read more here.
Keywords: phosphatase; inhibitor; falciparum; parasite growth ... See more keywords
Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23927
Abstract: Malaria remains one of the deadliest diseases worldwide and it is caused by the protozoan parasite Plasmodium spp. Parasite visualization is an important tool for the correct detection of malarial cases but also to understand… read more here.
Keywords: malaria parasite; parasite plasmodium; live let; let dye ... See more keywords
Trained immunity from the perspective of Plasmodium Infection.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250268
Abstract: The immune system of vertebrates includes innate immunity and adaptive immunity, and the network between them enables the host to fight against invasions of various pathogens. Recently, studies discovered that immune memory is one of… read more here.
Keywords: plasmodium; trained immunity; immunity; innate immune ... See more keywords
Molecular characterization and expression profile of an alternate proliferating cell nuclear antigen homolog PbPCNA2 in Plasmodium berghei
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2036
Abstract: Proliferative cell nuclear antigen (PCNA) is the processivity factor for various DNA polymerases and it functions in response to DNA damage in eukaryotic system. Plasmodium falciparum contains two PCNAs, while PCNA1 has been attributed to… read more here.
Keywords: cell nuclear; pbpcna2; physiology; expression ... See more keywords
Quantitative Proteomic Analysis of Simian Primary Hepatocytes Reveals Candidate Molecular Markers for Permissiveness to Relapsing Malaria Plasmodium cynomolgi
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900021
Abstract: A major obstacle impeding malaria research is the lack of an in vitro system capable of supporting infection through the entire liver stage cycle of the parasite, including that of the dormant forms known as… read more here.
Keywords: quantitative proteomic; primary hepatocytes; infection; liver stage ... See more keywords
Structure–function analysis of cysteine residues in the plasmodium falciparum chitinase, PfCHT1
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4289
Abstract: The Plasmodium ookinete uses chitinase activity to penetrate the acellular, chitin‐containing peritrophic matrix to invade the mosquito vector. Plasmodium ookinetes from different parasite clades secrete two structurally distinct forms of chitinase, one, a short form… read more here.
Keywords: chitinase; chitin; plasmodium; pfcht1 ... See more keywords
Development of a rapid HRM qPCR for the diagnosis of the four most prevalent Plasmodium lineages in New Zealand
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DOI: 10.1007/s00436-017-5452-8
Abstract: Although wildlife rehabilitation and translocations are important tools in wildlife conservation in New Zealand, disease screening of birds has not been standardized. Additionally, the results of the screening programmes are often difficult to interpret due… read more here.
Keywords: plasmodium; hrm qpcr; new zealand;
Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology Research"
DOI: 10.1007/s00436-018-5924-5
Abstract: Currently, there are very few studies of avian malaria that investigate relationships among the host-vector-parasite triad concomitantly. In the current study, we experimentally measured the vector competence of several Culex mosquitoes for a newly described… read more here.
Keywords: vector; avian malaria; homopolare; blood ... See more keywords
Erythrocyte membrane proteins involved in the immune response to Plasmodium falciparum and Plasmodium vivax infection.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-021-07135-6
Abstract: Invasion of Plasmodium into the red blood cell involves the interactions of a substantial number of proteins, with red cell membrane proteins as the most involved throughout the process from entry to exit. The objective… read more here.
Keywords: membrane proteins; response; falciparum; infection ... See more keywords
Preparation, characterization, and evaluation of eosin B–loaded nano-liposomes for growth inhibition of Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology Research"
DOI: 10.1007/s00436-021-07395-2
Abstract: Malaria is a deadly disease in humans caused by the Plasmodium parasite. High prevalence of malaria and resistance of malaria parasite to currently proposed drugs have increased the need to introduce and use new and… read more here.
Keywords: eosin loaded; nano liposomes; drug; plasmodium ... See more keywords
Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics
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DOI: 10.1007/s11306-019-1630-2
Abstract: Despite the advances in diagnosis and treatment, malaria has still not been eradicated. Metabolic interactions between the host and Plasmodium may present novel targets for malaria control, but such interactions are yet to be deciphered.… read more here.
Keywords: infected plasmodium; high resolution; metabolic alterations; resolution metabolomics ... See more keywords