Plasmodium 18S Ribosomal RNA Biomarker Clearance After Food and Drug Administration–Approved Antimalarial Treatment in Controlled Human Malaria Infection Trials
Sign Up to like & getrecommendations! Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofad202
Abstract: Abstract Background Sensitive molecular assays, such as quantitative reverse-transcription polymerase chain reaction (qRT-PCR) of Plasmodium 18S ribosomal RNA (rRNA), are increasingly the primary method of detecting infections in controlled human malaria infection (CHMI) trials. However,… read more here.
Keywords: clearance; 18s ribosomal; biomarker; plasmodium 18s ... See more keywords
Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood
Sign Up to like & getrecommendations! Published in 2018 at "Malaria Journal"
DOI: 10.1186/s12936-018-2422-2
Abstract: BackgroundPlasmodium 18S rRNA is a biomarker used to monitor blood-stage infections in malaria clinical trials. Plasmodium sporozoites also express this biomarker, and there is conflicting evidence about how long sporozoite-derived 18S rRNA persists in peripheral… read more here.
Keywords: plasmodium 18s; 18s rrna; peripheral blood; rrna ... See more keywords
Utilization of 18s ribosomal RNA LAMP for detecting Plasmodium falciparum in microscopy and rapid diagnostic test negative patients
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0275052
Abstract: In this study, Plasmodium falciparum was detected in patients that were declared negative for malaria microscopy and rapid diagnostic test kit (mRDT), using Plasmodium 18s rRNA loop-mediated isothermal amplification (LAMP) technique. The main aim of… read more here.
Keywords: lamp; plasmodium; microscopy; 18s rrna ... See more keywords