Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei
Sign Up to like & getrecommendations! Published in 2018 at "Mammalian Genome"
DOI: 10.1007/s00335-018-9752-9
Abstract: Malaria is a common and sometimes fatal disease caused by infection with Plasmodium parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium falciparum parasites which features a complex immunopathology that includes… read more here.
Keywords: cerebral malaria; model; mouse model; plasmodium berghei ... See more keywords
Mice chronically fed a high-fat diet are resistant to malaria induced by Plasmodium berghei ANKA
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06427-2
Abstract: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) develop neurological symptoms and die 6-–7-day post-inoculation in the absence of high parasitemia. The effects of chronic intake of a high-fat diet on this process are largely… read more here.
Keywords: fat diet; malaria; plasmodium berghei; high fat ... See more keywords
The Metabolomic Profiles of Sera of Mice Infected with Plasmodium berghei and Treated by Effective Fraction of Naja naja oxiana Using 1H Nuclear Magnetic Resonance Spectroscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Acta parasitologica"
DOI: 10.1007/s11686-021-00456-7
Abstract: BACKGROUND The use of venom fractions from the Iranian cobra could be useful adjunct treatments of malaria with chloroquine. A metabolomic investigation with 1HNMR spectroscopy was conducted on an effective fraction tested earlier using Plasmodium… read more here.
Keywords: mice infected; effective fraction; plasmodium berghei; spectroscopy ... See more keywords
Synthesis, β-hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei: A promising antimalarial agent.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.10.051
Abstract: Many people are affected by Malaria around the world, and the parasite is developing resistance against available drugs. Currently, isoquine and N-tert-butyl isoquine are some of the most promising antimalarial candidates that have already reached… read more here.
Keywords: dehydroxy isoquine; inhibition; plasmodium berghei; isoquine derivatives ... See more keywords
Comparative genomics and proteomic analyses between lethal and nonlethal strains of Plasmodium berghei.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2018.01.001
Abstract: Plasmodium berghei (Pb) XAT, a rodent malaria parasite, is an irradiation-attenuated variant derived from the lethal strain Pb NK65. Differences in genome sequence, protein structure and function between Pb XAT and Pb NK65 are currently… read more here.
Keywords: comparative genomics; deficient; rap2; infection ... See more keywords
Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2023438118
Abstract: Significance A better understanding of the molecular mechanisms underlying the development of Plasmodium parasites in Anopheles mosquitoes would facilitate the development of malaria vaccines and of novel strategies to interrupt disease transmission. We characterized, at… read more here.
Keywords: development; gene expression; plasmodium berghei;
Plasmodium berghei Purified Hemozoin Associated with DNA Strongly Inhibits P. berghei Liver-Stage Development in BALB/c Mice after Intravenous Inoculation
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00304-22
Abstract: In the acidic lysosome-like digestive vacuole, Plasmodium parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen… read more here.
Keywords: plasmodium; plasmodium berghei; hemozoin; liver stage ... See more keywords
Characterization of Plasmodium berghei Pbg37 as Both a Pre- and Postfertilization Antigen with Transmission-Blocking Potential
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00785-17
Abstract: Transmission-blocking vaccines (TBVs) interrupting malaria transmission are an integrated tool for malaria eradication. We characterized a sexual-stage-specific gene (PBANKA_060330) from Plasmodium berghei and studied its potential for use as a TBV. ABSTRACT Transmission-blocking vaccines (TBVs)… read more here.
Keywords: transmission; pbg37; plasmodium berghei; transmission blocking ... See more keywords
Suppressive effect of goat bile in Plasmodium berghei ANKA infection in mice
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary World"
DOI: 10.14202/vetworld.2021.2016-2022
Abstract: Abstract Background and Aim: Some individuals in Indonesia consume intact goat gallbladder to prevent and treat malaria. The acute and subacute toxicity tests of goat bile (GB) have shown mild diarrhea in mice. Therefore, this… read more here.
Keywords: goat bile; berghei anka; suppressive effect; plasmodium berghei ... See more keywords
Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2020-0046
Abstract: Abstract Objectives Broad spectrum antimalarial drugs without deleterious effects on mitochondria are scarce. It is in this regard that we investigated the potency of methanol extract and solvent fractions of Phyllanthus amarus on chloroquine-susceptible and… read more here.
Keywords: dichloromethane fraction; effects mitochondrial; fractions phyllanthus; plasmodium berghei ... See more keywords
Carica papaya augments anti-malarial efficacy of artesunate in Plasmodium berghei parasitized mice.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of parasitology"
DOI: 10.17420/ap6702.342
Abstract: Drug-herb interaction may lead to therapeutic failure or toxicities. This study investigates the effect of methanol extract of Carica papaya (papaya) on anti-malarial efficacy of artesunate and on hepato-renal toxicities in Plasmodium berghei infected mice.… read more here.
Keywords: carica papaya; group; mice; plasmodium berghei ... See more keywords