Automated Recognition of Plasmodium falciparum Parasites from Portable Blood Levitation Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105396
Abstract: In many malaria‐endemic regions, current detection tools are inadequate in diagnostic accuracy and accessibility. To meet the need for direct, phenotypic, and automated malaria parasite detection in field settings, a portable platform to process, image,… read more here.
Keywords: blood; falciparum parasites; plasmodium falciparum; detection ... See more keywords
Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models
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DOI: 10.1002/advs.202202944
Abstract: Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum enables their sequestration via attachment to the microvasculature. This artificially increases the dwelling time of the infected red blood cells within inner organs… read more here.
Keywords: plasmodium falciparum; neuronal implications; malaria neuronal; implications plasmodium ... See more keywords
Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase **
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100704
Abstract: Plasmodium falciparum cGMP‐dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole‐based compounds are potent ATP… read more here.
Keywords: plasmodium falciparum; protein kinase; competitive inhibitors; falciparum cgmp ... See more keywords
Rational Optimization of Dihydropyrimidinone‐Quinoline Hybrids as Plasmodium falciparum Glutathione Reductase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200034
Abstract: A series of dihydropyrimidinone‐based antimalarial compounds were designed and synthesised based on the previously identified amide‐based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on… read more here.
Keywords: plasmodium falciparum; glutathione reductase; dihydropyrimidinone; falciparum glutathione ... See more keywords
Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase
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DOI: 10.1002/cmdc.202200411
Abstract: A series of 22 different 3,5‐diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones (DATPs) were synthesized, characterized, and screened for their in vitro antiplasmodial activities against chloroquine (CQ)‐sensitive Pf3D7, CQ‐resistant PfINDO, and artemisinin‐resistant PfMRA‐1240 strains of Plasmodium falciparum. DATP 19 (3,5‐bis(4‐hydroxy‐3,5‐dimethoxybenzylidene)tetrahydro‐2H‐pyran‐4(3H)‐one) was found… read more here.
Keywords: plasmodium falciparum; pyran ones; tetrahydro pyran; diarylidenetetrahydro pyran ... See more keywords
Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine‐2,4‐diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase
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DOI: 10.1002/cmdc.202200418
Abstract: A series of 5‐[(phenethylamino)methyl]pyrimidine‐2,4‐diamines were assessed in silico as potential inhibitors of Plasmodium falciparum dihydrofolate reductase (PfDHFR), synthesised and tested for inhibitory activity against PfDHFR in vitro. The compounds displayed promising inhibitory activity against both wild‐type… read more here.
Keywords: plasmodium falciparum; falciparum dihydrofolate; inhibitors plasmodium; pyrimidine diamines ... See more keywords
N2' -Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300211
Abstract: Twelve N2'-branched acyclic nucleoside phosphonates and bisphosphonates were synthesized as potential inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT), the key enzyme in the purine salvage pathway for production of purine nucleotides. The chemical structures were… read more here.
Keywords: plasmodium falciparum; nucleoside phosphonates; branched acyclic; acyclic nucleoside ... See more keywords
Centromere and its associated proteins—what we know about them in Plasmodium falciparum
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DOI: 10.1002/iub.1878
Abstract: The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the… read more here.
Keywords: centromere associated; associated proteins; falciparum; plasmodium falciparum ... See more keywords
The structure of Plasmodium falciparum 3D7_0606800 reveals a bi‐lobed architecture that supports re‐annotation as a Venus Flytrap protein
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3218
Abstract: Plasmodium falciparum, the causative agent of malaria, employs a diverse array of surface displayed proteins to promote dissemination and establish infection in the human host. Of these, Pf3D7_0606800 is highly immunogenic and has been designated… read more here.
Keywords: venus flytrap; pf3d7 0606800; lobed architecture; plasmodium falciparum ... See more keywords
Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4279
Abstract: Plasmodium falciparum plasmepsin X (PfPMX), involved in the invasion and egress of this deadliest malarial parasite, is essential for its survival and hence considered as an important drug target. We report the first crystal structure… read more here.
Keywords: zymogen; pfpmx; mature enzyme; plasmodium falciparum ... See more keywords
Employing Transgenic Parasite Strains to Study the Ca2+ Dynamics in the Human Malaria Parasite Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9018-4_14
Abstract: Studying Ca2+ dynamics in protozoan parasites is not an easy task. Loading of parasites with commonly used Ca2+ fluorescent dyes (such as Fuo4-AM) remains as the major protocol to measure the Ca2+ oscillations inside the… read more here.
Keywords: ca2 dynamics; plasmodium falciparum; study ca2; biology ... See more keywords