Trained immunity from the perspective of Plasmodium Infection.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250268
Abstract: The immune system of vertebrates includes innate immunity and adaptive immunity, and the network between them enables the host to fight against invasions of various pathogens. Recently, studies discovered that immune memory is one of… read more here.
Keywords: plasmodium; trained immunity; immunity; innate immune ... See more keywords
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.02.047
Abstract: Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration… read more here.
Keywords: rbc dehydration; piezo1 allele; plasmodium infection;
Asymptomatic Plasmodium infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire.
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2019.107845
Abstract: AIMS We investigated the cross-sectional associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Côte d'Ivoire. METHODS We studied 979 participants (non-pregnant; no treated diabetes; 51% males; 18-87… read more here.
Keywords: plasmodium; south central; central ivoire; plasmodium infection ... See more keywords
Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical Plasmodium Infection Models.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00640
Abstract: Combination therapies have emerged to mitigate Plasmodium drug resistance, which has hampered the fight against malaria. M5717 is a potent multistage antiplasmodial drug under clinical development, which inhibits parasite protein synthesis. The combination of M5717… read more here.
Keywords: infection; plasmodium infection; activity m5717; combination ... See more keywords
Plasmodium infection and dysbiosis: A new paradigm in the host–parasite interaction
Sign Up to like & getrecommendations! Published in 2023 at "Parasite Immunology"
DOI: 10.1111/pim.12980
Abstract: The mucosal immune system contributes for the largest component of the tissue immune system due to its massive surface area and constant exposure to the microbiota. The gut microbiota comprises a complex micro‐ecosystem in the… read more here.
Keywords: plasmodium infection; interaction; dysbiosis; gut microbiota ... See more keywords
Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting Liver-Stage Plasmodium Infection
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02218-21
Abstract: Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a potent multistage antimalarial activity. ABSTRACT Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a… read more here.
Keywords: plasmodium; stage plasmodium; liver stage; stage ... See more keywords
Assessment of subpatent Plasmodium infection in northwestern Ethiopia
Sign Up to like & getrecommendations! Published in 2020 at "Malaria Journal"
DOI: 10.1186/s12936-020-03177-w
Abstract: Ethiopia has set a goal for malaria elimination by 2030. Low parasite density infections may go undetected by conventional diagnostic methods (microscopy and rapid diagnostic tests) and their contribution to malaria transmission varies by transmission… read more here.
Keywords: subpatent; subpatent infections; plasmodium infection; microscopy ... See more keywords
Malaria preventive practices and delivery outcomes: A cross-sectional study of parturient women in a tertiary hospital in Eastern Uganda
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0237407
Abstract: Background Uganda ranks third in the number of deaths attributable to malaria and has some of the highest recorded malaria transmission rates in the general population. Malaria in Pregnancy is associated with detrimental effects for… read more here.
Keywords: microscopy; malaria preventive; plasmodium infection; blood ... See more keywords
Anopheles gambiae Actively Metabolizes Uric Acid Following Plasmodium Infection to Limit Malaria Parasite Survival
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.821869
Abstract: Characterizing the physiological changes that accompany malaria parasite infection of the mosquito host is crucial to our understanding of vectorial capacity in Anopheles mosquitoes, yet has not fully been explored. In this study, we examine… read more here.
Keywords: plasmodium infection; infection; malaria parasite; metabolism ... See more keywords